Liposomes are well-known drug delivery systems that have been mainly used for anticancer drugs. From the initial hope to achieve a higher anticancer efficacy, thanks to a better tumour accumulation of liposomal drugs with respect to free drugs by EPR effects, several studies showed that basic liposomes are mainly useful to decrease drugs' side effects. Our research is directed to investigate targeted liposomes, by mAbs or mAbs' fragments, and stable liposome coatings.
De Martin S, Sarcognato S, Gabbia D, Canato E, Colognesi M, Cazzagon N, Guido M, Pasut G. A novel HER2-targeted liposomal formulation reduces the risk of hepatotoxicity induced by PEG-based anticancer drugs. Dig Liver Dis. 2020;52:e30-e31. doi: 10.1016/j.dld.2019.12.115
Alajati A, D'Ambrosio M, Troiani M, Mosole S, Pellegrini L, Chen J, Revandkar A, Bolis M, Theurillat JP, Guccini I, Losa M, Calcinotto A, De Bernardis G, Pasquini E, D'Antuono R, Sharp A, Figueiredo I, Nava Rodrigues D, Welti J, Gil V, Yuan W, Vlajnic T, Bubendorf L, Chiorino G, Gnetti L, Torrano V, Carracedo A, Camplese L, Hirabayashi S, Canato E, Pasut G, Montopoli M, Rüschoff JH, Wild P, Moch H, De Bono J, Alimonti A. CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo. J Clin Invest. 2020;130(5):2435-2450. doi: 10.1172/JCI131133.
Catanzaro D, Nicolosi S, Cocetta V, Salvalaio M, Pagetta A, Ragazzi E, Montopoli M, Pasut G. Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells. Oncotarget. 2018;9:16847-16860. doi: 10.18632/oncotarget.24708
Pasut G, Paolino D, Celia C, Mero A, Joseph AS, Wolfram J, Cosco D, Schiavon O, Shen H, Fresta M. Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy. J Control Release. 2014;199:106-113. doi: 10.1016/j.jconrel.2014.12.008.
