Giovanni Marzaro
 | Department of Pharmaceutical and Pharmacological Sciences, University of Padova Position: Tenure track Researcher on Medicinal Chemistry (SSD CHIM/08) Contacts |
Short CV
Born in Venice on 03/09/1978
1998-1999: employed at the Laboratory of Analysis of Micropollutant Organic Compounds, INCA Consortium, Venice
2005: Degree summa cum laude in Pharmaceutical Chemistry and Technology, University of Padova
2006-2008: PhD in Molecular Sciences – Medicinal Chemistry Degree, Dept of Pharmaceutical and Pharmacological Sciences, University of Padova (Supervisor: Prof. Adriana Chilin)
2008-2014: PostDoc at Dept of Pharmaceutical and Pharmacological Sciences, University of Padova (Supervisor: Prof. Adriana Chilin)
2014 – present: tenure track researcher of Medicinal Chemistry at Dept of Pharmaceutical and Pharmacological Sciences, University of Padova
Teaching
Courses
Laboratory of synthesis and extraction of drugs, Degree in Pharmaceutical Chemistry and Technology, 75 hours, 5 CFU
Office hours
every day, upon appointment
Availability for Thesis Projects
Topics for experimental thesis
- Synthesis and study of kinase inhibitors
- Synthesis and study of multi targeting compounds with anti-tyrosine kinase and anti-HDAC activities
- Synthesis and study of organoselenium anticancer compounds
Available positions: 4 positions a year (starting periods: first half of February, first half of October)
Topics for non-experimental thesis
- Target therapy for cancer treatment
Research
Scientific Activities
Synthesis of ATP-mimic compounds as kinase inhibitors. Development of novel strategies for the synthesis of quinazoline and pyrimidine based kinase inhibitors. Use of green chemistry strategies (microwave assisted organic synthesis). Evaluation of the compounds activity against isolated kinases. Rationalization of activity profile through 3D-QSAR modelling.
Synthesis and study of dual targeting compounds (dual kinase/tubulin polymerization inhibitors; dual kinase/HDAC inhibitors).
Synthesis of organoselenium compounds as novel anticancer compounds. Development of novel strategies for the synthesis of selenium-containing organic compounds.
Synthesis of NF-kB inhibitors.
Use of spectroscopic techniques (IR, 1H-NMR, 13C-NMR, homonuclear and heteronuclear 2D-NMR) for the exhaustive characterization of organic compound structures.
Member of the Italian Society of Chemistry (SCI, Societa Chimica Italiana) – Medicinal Chemistry Division
Member of the Editorial Board for Scientific Reports (Nature Publishing Group)
Peer reviewer for international journals on Organic Synthesis and Medicinal Chemistry.
Guest Editor for the international peer-reviewed journal Current Topics on Medicinal Chemistry.
Technical expertise
Organic synthesis
Microwave Assisted Organic Synthesis
Purification techniques
Flash Chromatography
IR Spectroscopy
1D and 2D NMR Spectroscopy
Mass Spectrometry
3D-QSAR modelling
Publications
- V. Gandin, A. Ferrarese, M. Dalla Via, C. Marzano, A. Chilin, G. Marzaro. Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily. Sci. Rep. 5, 16750 (2015). DOI: 10.1038/srep16750 IF: 5,578 Ranking: Q1 (category: multidisciplinary sciences)
- G. Marzaro, A. Coluccia, A. Ferrarese, P. Brun, I. Castagliuolo, M.T. Conconi, G. La Regina, R. Bai, R. Silvestri, E. Hamel, A. Chilin - Discovery Of Biarylaminoquinazolines As Novel Tubulin Polymerization Inhibitors. J. Med. Chem., 57, 4598-605 (2014) DOI:10.1021/jm500034j IF: 5,447 Ranking: Q1 (category: medicinal chemistry)
- G. Marzaro, A. Guiotto, M. Borgatti, A. Finotti, R. Gambari, G. Breveglieri, A. Chilin - Psoralen derivatives as inhibitors of NF-κB/DNA interaction: synthesis, molecular modeling, 3D-QSAR and biological evaluation. J. Med. Chem.56, 1830-1842 (2013), DOI: 10.1021/jm3009647. IF: 5,408 Ranking: Q1 (category: medicinal chemistry)
- G. Marzaro, A. Chilin, A. Guiotto, E. Uriarte, P. Brun, I. Castagliuolo, F. Tonus, H. Gonzàlez-Diaz – Using the TOPS-MODE approach to fit multi-target QSAR models for tyrosine kinases inhibitors. – Eur. J. Med. Chem. 46, 2185-2192 (2011), DOI: 10.1016/j.ejmech.2011.02.072. IF: 3,432 Ranking: Q1 (category: medicinal chemistry)
- A. Chilin, M.T. Conconi, G. Marzaro, A. Guiotto, L. Urbani, F. Tonus, P. Parnigotto. - Exploring Epidermal Growth Factor Receptor (EGFR) inhibitor features: the role of fused dioxygenated rings on the quinazoline scaffold. - J. Med. Chem., 53, 1862-1866 (2010). DOI: 10.1021/jm901338g. IF: 5,207 Ranking: Q1 (category: medicinal chemistry)
Patents
A. Chilin, G. Marzaro, A. Guiotto, M.T. Conconi, I. Castagliuolo. - Biphenyl tricyclic quinazoline compounds – International Patent. Application No. PCT/EP2012/055145 (22.03.2012), Pubblication No. WO2012127012 (27.09.2012).
Research projects and Funds
2014-2015 - Design and synthesis of improved analogs of trimethylangelicin (TMA) for personalized treatment of cystic fibrosis, Fondazione Fibrosi Cistica, Progetto FFC #8/2014, P
2013-2014 – Small molecules protein-protein interaction inhibitors (SMPPIIs) for egfr inhibition: the grain of sand that blocks the gear of cancer, Young Scientist Awards, University of Padova, A.00000.D100.PRGRMARZ12, PI
2012-2013 - Novel histone deacetylase inhibitors to obtain pluripotent stem cells from human fibroblasts, Progetto di Ateneo 2008, Università di Padova, CPDA120753, P
2011-2013 Progettazione ligand-based e sintesi di nuove molecole per la scoperta di agenti antitumorali attivi come modulatori del ciclo cellulare, PRIN-2009, MIUR - Italian Ministry of Scientific Research, Protocollo 2009PX2T2E_001, P
2010-2011 - Molecular characterization of trimethylangelicin (TMA) and structurally-related compounds in CF lung disease: anti-inflammatory effects and potentiation of the CFTR biological activity, Fondazione Fibrosi Cistica, Progetto FFC #17/2010, P
2009-2010 Progettazione razionale, sintesi e valutazione biologica di nuovi inibitori delle tirosin-chinasi: uno studio ad "equilibrio circolare", Progetto di Ateneo 2008, Università di Padova, CPDA084954/08, P
