Stefano Dall'Acqua
Department of Pharmaceutical and Pharmacological Sciences, University of Padova Contacts |
Short CV
Born on 24/05/1974
1998: Degree summa cum laude in Chemistry and Pharmaceutical Technology, University of Padova
1999-2002: PhD in Pharmaceutical Sciences, Dept of Pharmaceutical Sciences, University of Padova (Supervisor: prof Elsa Mariella Cappelletti)
2002-2005: Post-Doc Dept of Pharmaceutical Sciences, University of Padova (Supervisor: Prof Gabbriella Innocenti)
2005-2007: Research Fellow of Department of Pharmaceutical Sciences
2007-present:Researcher, Assistant professor (SSD CHIM08)
Teaching
Office hours
Monday morning 10-12, on request by e-mail contact
Availability for Thesis Projects
Experimental thesis on Natural Product Chemistry are available. Three main area of research are available for thesis, namely extraction, isolation and characterization of bioactive natural products; development of analytical methods for the natural product determination in complex matrix; metabolomic-based studies on natural products.
Research
Scientific Activities
The research activity of the Natural Product Lab deal with the chemistry of natural products mainly plant derived bioactive constituents. Research projects can be grouped in three different area, extraction, isolation and characterization of bioactive natural products, bioavailability and in vivo effects of natural products and nutraceuticals, metabolomics-based studies on natural products. In the first area innovative extraction protocols have been evaluated by Supercritical CO2, in cooperation with other research groups, furthermore approaches using enzymes, NADES are actually studied. Structure elucidation of newly isolated natural product is obtained by accurate measurements by 1D and 2D NMR techniques as well as HR-MS and MS/MS approaches using different Mass spectrometer analyzer (Ion trap, TQD, Q-TOF). In the last years some projects were dedicated to the study of the bioavailability and in vivo effects of natural mixtures and isolated natural products.
Research group has international relationships with Brno Pharmaceutical and Veterinary Faculty (Czech Republic), Ankara University (Turkey), Thribuvan University (Nepal), Universidad Estatal Amazonica. Several cooperation with Italian groups have been established especially with Trieste, Camerino, La Sapienza (Roma), Universities.
Technical expertise
Monodimensional and bidimensional NMR (including COSY, TOCSY, NOESY, ROESY, HSQC, HSQC-DEPT, HMBC, HMQC, diffusion experiments and DOSY, quantitative H-NMR on mixtures and biofluids).
GC-MS (ion trap) methods development for essential oils, and for metabolites on biofluids, using both EI and CI ionization.
HPLC-MS by Ion trap, for qualitative and quantitative purpouses, mainly on natural products of herbal origins. HPLC-MS triple quadrupole for quantitative analysis of selected compounds on complex mixtures and on biofluids.
UPLC-Q-TOF analysis for metabolomics purpouses on herbal extracts
HPLC-MS, UPLC-MS on urines and biofluids for determination of bioactive natural products.
Positions available
no positions are actually available
Publications
- Dall'Acqua, S.; Perissutti, B.; Grabnar, I.; Farra, R.; Comar, M.; Agostinis, C.; Caristi, G.; Golob, S.; Voinovich, D. Pharmacokinetics and immunomodulatory effect of lipophilic Echinacea extract formulated in softgel capsules. Eur. J. Pharm. Biopharm. 2015, 97, 8-14. (IF 3.850, 5-years IF 4.616) Q1
- Dall'acqua, S. Natural products as antimitotic agents. Current Topics in Medicinal Chemistry 2014, 14, 2272-2285. (IF 3.402, 5-years IF 3.632) Q1
- Dall'Acqua, S.; Linardi, M. A.; Bortolozzi, R.; Clauser, M.; Marzocchini, S.; Maggi, F.; Nicoletti, M.; Innocenti, G.; Basso, G.; Viola, G. Natural daucane esters induces apoptosis in leukaemic cells through ROS production. Phytochemistry 2014, 108, 147-156. (IF 2.547; 5-years IF 3.278) Q2
- Dall'Acqua, S.; Stocchero, M.; Clauser, M.; Boschiero, I.; Ndoum, E.; Schiavon, M.; Mammi, S.; Schievano, E. Changes in urinary metabolic profile after oral administration of curcuma extract in rats. J. Pharm. Biomed. Anal. 2014, 100, 348-356. (IF 2.979, 5-years 2.867) Q1
- 5 Malagoli, M.; Schiavon, M.; Dall’Acqua, S.; Pilon-Smits, E. A. H. Effects of selenium biofortification on crop nutritional quality. Front. Plant Sci. 2015, 6, 1-5. (IF 3.948 , 5-years 3.990) Q1
Research projects and Funds
2007-2014 Ex 60% Projects University of Padova
University PRAT 2011 CPDA118080 The antioxidant myth: evaluation of natural antioxidant by metabolomics approach.
2008 - 2015: Ex 60% Projects, University of Padova, PI. Extraction and Charactherization of bioactive natural products.
2007-Present: several projects are founded by private industries of Pharmaceutical, Nutraceutical, Cosmetic, Agricultural areas.
