Raffaella Filippini
 | Department of Pharmaceutical and Pharmacological Sciences, University of Padova Contacts |
Short CV
Raffaella Filippini - Associate Professor of Pharmaceutical Biology (SSD BIO/15).
1988 graduated at the University of Padova (Faculty of Pharmacy) with a degree in Pharmacy
1987-1988 Guest researcher at Laboratory of Mass Spectrometry dr. Traldi, CNR (Padova)
1991-1992 Guest researcher at Ecole Nationale Superieure d'Agronomie et des Industries Alimentaires Prof. Bourgaud - Nancy France
1990 Researcher in Faculty of Pharmacy at Padua University
from 2006 Associated Professor at the Faculty of Pharmacy of University of Padua
Member of the Accreditation and Assessment Group (GAV) for degree course in Applied and Pharmaceutical Sciences.
Member of Società Italiana di Fitochimica (SIF) and Società Italiana di Fitoterapia (SIFit).
Author of publications of international and national journals.
Her main scientific interests are in the field of medicinal plants with the following research lines:
- morphological and chemical characterization of plants with pharmaceutical and toxicological interest;
- chemical characterization and identification of new natural source of biologically active compounds;
- biosynthesis and accumulation of natural products in plant cell cultures;
- development of new analysis approaches for natural products;
- in vitro secondary metabolites production and micropropagation of medicinal plants;
- characterization of enzymatic activity in plant cell culture to obtain valuable derivatives with industrial prospects.
Teaching
Office hours
Every day by e-mail appointment
Availability for Thesis Projects
Positions for experimental and article-based theses are available. The main experimental activities concern plant cell cultures and medicinal plant study. Self-proposed article-based thesis arguments are also welcome. Contact us for more informations.
Research
Scientific Activities
1. Plants both as source of important secondary metabolites useful for pharmaceutical purposes and as food ingredients with the following research lines:
- identification and chemical characterization of new natural source of biologically active compounds;
- development of new analysis approaches for natural products;
- use sustainable and conservation solutions: biosynthesis and accumulation of natural products in in vitro cell cultures, development of systems for in vitro secondary metabolites production, and micropropagation of medicinal and endangered plants;
- morphological, histochemical, ultrastructural and chemical characterization of plants with pharmaceutical/food and toxicological interest;
- characterization of enzymatic activity in plant cell culture to obtain valuable derivatives with industrial prospects;
- in vitro biocatalysis and enzyme production to develop processes in enabling green chemistries;
2. Algae both as food resource and raw material for obtaining phytochemicals
Technical expertise
- in vitro plant cultures techniques under sterile conditions: callus and suspension cultures, micropropagation (direct and indirect organogenesis and somatic embryogenesis), and shoot and root cultures, selection of “high-producing” somaclones;
- secondary metabolite purification and characterization techniques (LC, TLC, HPLC, spectroscopy);
- pharmacognostic analysis techniques: macro- and micromorphology evaluation (stereomicroscopy, optical microscopy, SEM and TEM); histochemical analyses.
Publications
Marzocchi M, Badocco D, Piovan A, Pastore P, Di Marco V, Filippini R, Caniato R (2016) Metals in Undaria pinnatifida (Harvey) Suringar and Sargassum muticum (Yendo) Fensholt edible seaweeds growing around Venice (Italy). Journal of Applied Phycology 28 (4), pp. 2605-2613.
Catanzaro D, Filippini R, Vianello C, Carrara M, Ragazzi E, Montopoli M (2016) Chlorogenic acid interaction with cisplatin and oxaliplatin: Studies in cervical carcinoma cells. Natural Product Communications 11(4):499-502.
Matozzo V, De Notaris C, Finos L, Filippini R, Piovan A (2015) Environmentally realistic concentrations of the antibiotic Trimethoprim affect haemocyte parameters but not antioxidant enzyme activities in the clam Ruditapes philippinarum. Environmental Pollution 206:567-574.
Piovan A, Caniato R, Filippini R, Chiesura F, Dalla Vecchia F (2015) Morphological and phytochemical aspects of three alien Opuntia species on Euganean Hills in North-Eastern Italy. Plant Biosystems 149(4):788-796.
Piovan A, Caniato R, Filippini R (2014) Somatic embryogenesis and glucosinolate/myrosinase system in vulnerable Brassica repanda subsp. glabrescens (Poldini) Gómez-Campo. Scientia Horticulturae 172:317-324.
Piovan A, Filippini R, Innocenti G (2014) Coumarin compounds in Coronilla scorpioides callus cultures. Natural Product Communications 9(4):489-492.
Piovan A, Filippini R, Paoli MD, Bresin B (2014) TLC densitometric method for the preliminary evaluation of fucoxanthin-based products. Natural Product Research 28(14):1111-1115.
Piovan A, Seraglia R, Bresin B, Caniato R, Filippini R (2013) Fucoxanthin from undaria pinnatifida: Photostability and coextractive effects. Molecules 18(6):6298-6310.
Piovan A, Filippini R, Caniato R (2013) Crambe tataria: The Glucosinolate/myrosinase System in vivo and in vitro. Natural Product Communications 8(11):1615-1616.
Filippini R, Piovan A, Caniato R (2011) Substitution of Vaccinium myrtillus L. for Aronia melanocarpa (Michx.) Elliott in a commercial batch. Plant Biosystems 145(1):175-181.
Piovan A, Cassina G, Filippini R (2011) Crambe tataria: Actions for ex situ conservation. Biodiversity and Conservation 20(2):359-371.
Piovan A, Filippini R, Caniato R (2010) A semi-quantitative FIA-ESI-MS method for the rapid screening of Hypericum perforatum crude extracts. Natural Product Communications 5(3):431-434.
Piovan A, Cozza G, Caniato R, Moro S, Filippini R (2010) A novel glucosyltransferase from Catharanthus roseus cell suspensions. Process Biochemistry 45(5):655-659.
Filippini R, Piovan A, Borsarini A, Caniato R (2010) Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum. Fitoterapia 81(2):115-119.
Piovan A, Caniato R, Cappelletti EM, Filippini R (2010) Organogenesis from shoot segments and via callus of endangered Kosteletzkya pentacarpos (L.) Ledeb. Plant Cell, Tissue and Organ Culture 100(3):309-315.
Andreola B, Piovan A, Da Dalt L, Filippini R, Cappelletti E (2008) Unilateral mydriasis due to Angel's Trumpet. Clinical Toxicology 46(4):329-331.
