Patrizia Polverino de Laureto
 | Department of Pharmaceutical and Pharmacological Sciences, University of Padova Contacts |
Short CV
Doctor degree cum laude in Pharmaceutical Chemistry and Technologies at the University of Naples in 1986. Research activity at the Dept. of Organic Chemistry (head Prof. A. Fontana), University of Padova. In 1989: Research activity at the laboratory of protein sequencing (head Dr. G. di Prisco), Institute of Protein Biochemistry and Enzymology of CNR, Naples. From 1988 PhD-Course in Pharmaceutical Sciences at the University of Padova. 1991-1993: Fellowship from Pierrel SpA (Milan) at CRIBI Biotechnology Centre. In 1993 stage at the laboratory of Cellular Biology (head Dr. E. Appella), National Cancer Institute (Bethesda, USA). In the same year, stage at the Mass Spectrometry Laboratory (head Dr. M. Mann), European Molecular Biology Laboratory (Heidelberg, Germany). 1994-1996: Post-doctoral fellowship provided by University of Padua, at CRIBI Biotechnology Centre. In 1995: stage at the Mass Spectrometry Laboratory (head Prof. H. Morris), Imperial College of Science (London, UK). 1995-1997: Fellowship provided by Alfa-Wassermann (Bologna), at CRIBI Biotechnology Centre. January 1997-February 1998: Specialization in "Human Ecology", at University of Padova. 1997-2001: Assistant at CRIBI. 2001-2015: Researcher at University of Padova. Actual position: Associate professor in Biochemistry scientific area at the Department of Pharmaceutical and Pharmacological Sciences (University of Padova). She holds various institutional positions, including Chair of the Council of the Degree in Pharmaceutical Biotechnologies from AY 2015. She was a member of the Committee Research of the Department of Pharmaceutical and Pharmacological Sciences (DSF) of University of Padua and now is coordinator of the Didactic Committee of DSF.
Teaching - Professor of "Structural Biochemistry”, “Proteomics and Biochemical Methodologies” in the Master degree in Pharmaceutical Biotechnologies and "Analytical Biochemistry in the bachelor degree of Biotechnologies at University of Padua. She is the coordinator of several exchanges for mobility of students in the LLP/Erasmus program. Her research studies are dedicated to the biochemical and biophysical characterization of proteins and peptides and mainly concern the analysis of the amyloid aggregation states of proteins. In particular, she is interested in the process of amyloid aggregation of alpha-synuclein with the aim of clarifying at the molecular level the mechanism of aggregation and the role of this protein in the pathogenesis of Parkinson's disease. Recently, she was involved in a study dealing with the chemico-physical stability of protein drugs to real-life stressors.
She is involved in several international projects as a coordinator or participant. Publications, produced continuously over the years in international journals document the research consistent with the subject area of biochemistry.
Teaching
Office hours
Upon appointment
Availability for Thesis Projects
- Characterization of proteins involved in neurodegeneration.
- Stability of protein drugs under stressors
Research
Scientific Activities
Her research studies are dedicated to the biochemical and biophysical characterization of proteins and peptides and mainly concern the analysis of the aggregation states of proteins. In particular she is interested in the process of amyloid aggregation of alpha-synuclein with the aim of clarifying at the molecular level the mechanism of aggregation and the role of this protein in the pathogenesis of Parkinson's disease. She also studies the interaction between proteins and lipids, using biochemical and biophysical techniques. Of particular interest is her expertise in mass spectrometry and part of his research is dedicated to the development of new methodologies related to it.
Technical expertise
In our lab all the techniques for the purification (all types of chromatography and electrophoresis) and characterization of proteins and peptides are routinely used. In particular,for our research interest, we use spectroscopic techniques (CD, fluorescence and FT-IR spectroscopy) for the structural characterization of proteins. Of particular interest, our expertise in mass spectrometry analysis.
Research projects and Funds
• Assegno di Ricerca FSE (105-121-2121-2015): SVILUPPO DI METODI DI SPETTROMETRIA DI MASSA PER L’IDENTIFICAZIONE DI PROTEINE ALLERGENICHE, LORO MODIFICHE POST-TRADUZIONALI E STATO DI AGGREGAZIONE, 30/09/2016-29/09/2017, Responsabile scientifico
• Programma Nazionale di Ricerca in Antartide. (PNRA16_00068) BASI MOLECOLARI DELL’ADATTAMENTO DI DESCHAMPSIA ANTARCTICA E COLOBANTHUS QUITENSIS ALL’AUMENTO DELLA TEMPERATURA E ALLA DISPONIBILITÀ DI AZOTO, 5/12/2017, Responsabile scientifico dell’unità B
• Progetto di ricerca di Ateneo 2018. (POLV_SID17_01) (C93C18000026000) INSIGHT INTO THE INHIBITION MECHANISM OF -SYNUCLEIN AGGREGATION BY OLEUROPEIN AGLYCONE: A STRUCTURAL POINT OF VIEW, 01/01/2018, Responsabile scientifico
• Programma Nazionale di Ricerca in Antartide. (PNRA18_00147) IMPACT OF CLIMATE CHANGE ON PLANT-MICROBE INTERACTION: A FOCUS ON TRIPARTITE PLANT-FUNGUS-VIRUS RELATIONSHIP AND ON THEIR BIOACTIVE COMPOUNDS. Responsabile scientifico dell’unità B.
• Programa di ricerca di eccellenza. Fondazione Cariparo. (52012) THE ROLE OF BACTERIAL PROTEASES IN THROMBOSIS AND AMYLOIDOSIS. Partecipante al Programma di ricerca.
• Contratto per attività di ricerca dal titolo ANALISI DI IMPATTO CLINICO ED ECONOMICO DELL’ACIDO IALURONICO NEI PAZIENTI CON OSTEOARTROSI, finanziatore Isheo Srl, Responsabile scientifico.
• Contratto per attività di ricerca dal titolo HANDLING OF PROTEIN DRUG PRODUCTS per la caratterizzazione della stabilità di vaccini antiCOVID 19 Pfizer, Moderna e AstraZeneca, con l’ULSS 3 Serenissima.
• IMI2, Research and Innovation Action, (EU project 101007939) RIA: REAL WORLD HANDLING OF PROTEIN DRUGS - EXPLORATION, EVALUATION AND EDUCATION (RealHOPE), Responsabile scientifico locale.
• Programma Nazionale di Ricerca in Antartide. (PNRA22) BIODIVERSITY AND BIOPROSPECTING OF FUNGAL ENDOPHYTES FROM THE ANTARCTIC PLANT COLOBANTHUS QUITENSIS: A FOCUS ON MYCOVIRUSES (MYPLACE), Responsabile scientifico locale.
