Paolo Caliceti

Department of Pharmaceutical and Pharmacological Sciences, University of Padova
via F. Marzolo 5, 35131 Padova - Italy
Current Position:
Full Professor of Pharmaceutical Technology and Biopharmaceutics
Director of the Department of Pharmaceutical and Pharmacological Sciences of University of Padova

Contacts
Phone: +39-049-827-5695
Fax:  +39-049-827-5366
e-mail: paolo.caliceti@unipd.it
Skype: paolocaliceti

  Short CV

Education
1988: PhD in Pharmaceutical Sciences. University of Padova
1984: Master in Pharmaceutical Chemistry and Technology

Employment
Since 2002 Full Professor in Pharmaceutical Technology at University of Padova
1998-2002 Associate Professor in Pharmaceutical Technology at University of Padova
1989-1998 Assistant Professor in Applied Pharmceutical Chemistry at University of Padova
1989 Post-Doc CNR

Work abroad 
1986/1987 National Institute of Health, Bethesda
1990 Academy of Sciences of Moscow
1994 SmithKline Beecham Pharmaceuticals, King of Prussia, PA,USA

Teaching

  Courses

Educational offer in Syllabus

  1. Pharmaceutical Technology, Pharmaceutical Chemistry and Technology, ECTS  10, 64 hours frontal lectures and 30 hours bench teaching
  2. Biopharmaceutical Technology, ECTS 7, 56 frontal hours

  Office hours

Friday 8.30-9.30

  Availability for Thesis Projects

  1. Multifunctional polymeric bioconjugates for active tumor targeting
  2. Polymeric micelles for drug delivery
  3. Innovative supramolecular systems for transmebrane drug delivery
  4. Formulation of biotech drugs by physical and chemical polymer bioconjugtion

Research 

  Scientific Activities

Topics of work:

  1. Modification of bioactive peptides and proteins with soluble polymers;
  2. Lipid and polymeric biodegradable nano-/micro-particles for controlled protein and small drug delivery by supercritical techniques;
  3. Multifunctional macromolecules for protein and small drug delivery;
  4. New cyclodextrin based drug carriers; 
  5. Gold nanoaprticles as drug delivery systems;
  6. Functional responsive micelles, lipoosomes and polymersomes

Research products
Patents 17, Publications over 150; Invited presentations over 50

Other activities
Member of editoral boards of drug delivery journals; Member of international committees for science funding; President CRS Italy Chapter (2008-2013); Consultant with pharmaceutical companies.

 

 

  Technical expertise

  1. Design and synthesis of new biopolymers
  2. Design and development of  methodologies for tailored protein bioconjugation to biocompatible polymers
  3. Chemical technologies for small drug bioconjugation to biopolymers
  4. Design and development of smart colloidal formulations for protein and small drug delivery: micelles, liposomes and polymersomes.
  5. Production and physicochemical and biopharmaceutical charcaterization of lipid and polymeric nano- and microparticles for protein and small drug delivery by classical and innovative technologies ().
  6. Physicochemical and Biopharmaceutical characterization of biopolymers, supramolecular drug bioconjugates and colloidal drug delivery systems and nano- and microparticles: GPC, SEC, RP-HPLC, DLS-HPLC, MS, UV-Vis, IR, fluorescence, CD, NMR, elemental analysis, potentiometric analysis, chemical analysis, PCS, TEM, SEM, ITC, DSC, TGA, homogenizers, supercritical equipment, spray-drier, LS,  contact angle
  7. Pharmacokinetic studies
  8. Cell culture studies (cytotoxicity, cell selectivity, cell trafficking, cytofluorimetry, confocal microscopy, fluorescence microscopy).
  9. Immunolgical studies in vivo (ELISA)

  Positions available

  Publications

5 main publications of the last 10 years: 

  1. S. Salmaso, S. Bersani, A. Scomparin, F. Mastrotto, R. Scherpfer, G. Tonon, P. Caliceti. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjugate Chem. (2009) 20(6): 1179-1185.
  2. J. Pall Magnusson, S. Bersani, S. Salmaso, C. Alexander, P. Caliceti. In Situ Growth of Side-Chain PEG Polymers from Functionalized Human Growth Hormone-A New Technique for Preparation of Enhanced Protein-Polymer Conjugates. Bioconjugate Chem. (2010) 21(4): 671-678.
  1. S. Bersani, S. Salmaso, F. Mastrotto, E.Ravazzolo, A. Semenzato, P. Caliceti.  Star-like oligo-arginyl-maltotriosyl derivatives as novel cell-penetrating enhancers for the intracellular delivery of colloidal therapeutic systems, Bioconjugate Chem. (2012) 23 (7):1415–1425.
  2. Stefano Salmaso, Sara Bersani, Anna Scomparin, Anna Balasso, Chiara Brazzale, Michela Barattin, Paolo Caliceti A novel soluble supramolecular system for sustained rh-GH delivery J. Control. Release (2014) 28(194):168-177
  3. G. Bonzi , S. Salmaso, A. Scomparin, A. Eldar-Boock, R. Satchi-Fainaro , P. Caliceti. Novel Pullulan Bioconjugate for Selective Breast Cancer Bone Metastases Treatment Bioconj. Chemistry  (2015) 26(3): 489-501         

  Complete list of publications

Paolo Caliceti in Padua Research Archive IRIS (Institutional Research Information System) 

  Patents

1. F.M.Veronese, P. Caliceti, O. Schiavon, L. Sartore. A Method to maintain the activity in polyethylene  glycol-modified  proteolytic enzymes. PCT/EP93/00205.

2. F. M. Veronese, O. Schiavon, P. Caliceti, L. Sartore, Elisabetta Ranucci , P. Ferruti

Polymers of N-acryloylmorpholine activated at one end , conjugated with bioactive materials , surfaces U.S. Patent Application 08/243,869.

3. P. Ferruti, E. Ranucci, L. Sartore, P. Caliceti, O. Schiavon e F. M. Veronese. New chain terminated N-vinyl lactam polymer , grafts copolymers , methods for making same.US Patent, Application 08/112,077; PCT/EP93/306825.6.

4. M. J. Harris, F. M. Veronese, O. Schiavon , P. Caliceti. Multi-armed monofunctional , hydrolitically stable derivatives of poly (ethylene glycol), related polymers for modification of surfaces , molecules. US Patent , Application 08/371,065.

5. O. Schiavon, F. M. Veronese, P. Caliceti , P. Orsolini. Biologically active conjugates having a detector reporter moiety , method of identificationof said derivative. PCT/IB99/01957.

6. F. M. Veronese, P. Caliceti, O. Schiavon  et al.Solution-phase site-specific preparation of GRF-PEG conjugates. EP/97121264.

7. P. Caliceti, S. Salmaso, S. Bersani. Corona-like (guanidyl)-oligosaccharideic derivatives. PCTEP2011/050813.

8. P. Caliceti, S. Salmaso, S. Bersani. Preparation of corona-like (arginyl)-oligosaccharidic as cell-penetrating enhancers for intracellular delivery of colloidal therapeutic systems WO 2012097876 A1 20120726

9. A. Di Pietro, F.  Cavazza, P. Caliceti. Modified hyaluronic acid derivatives and use thereof. EP12187828.4.

10. G. Tonon, P. Caliceti, G. Orsini, R.  Schrepfer, F.  Selis. Modified polyethylene glycols and their supramolecular complexes with biologically active macromolecules. WO2013054298 A2 20130418.

11. G. Baratto, A. Semenzato, P. Caliceti. Microparticles of epidermal lipids containing polyalcohol for the preparation of cosmetic or pharmaceutical compositions. WO2011114214 A2 2011.

  Research projects

  1. Novel biopolymers for drug delivery
  2. Physical PEGylation of proteins and peptides
  3. Chemical PEGylation of proteins and peptides
  4. Pullulan bioconjugates for active tumor targeting
  5. New cell penetration enhancers
  6. Novel systems for active delivery of siRNA and miRNA
  7. PEG based micelles for small drug delivery
  8. Supramolecular colloidal formulations for ocular delivery
  9. Lipid and polymeric nano- and microparticles for protein and small drug delivery