Nicola Realdon
Department of Pharmaceutical and Pharmacological Sciences, University of Padova Position: Associate Professor Pharmaceutical Technology and Legislation (CHIM09) Contacts |
Short CV
1985: Degree in Pharmaceutical Chemistry and Technology at the University of Padova (Italy)
1986: Army officer of the Force Artillery
1987: Beckton Dickinson medical technology company
1988: ISTITUTO BIOCHIMICO: R&D Director
1992 – 2002: Assistant professor of Pharmaceutical Technology and Legislation (CHIM 09)
2002 – …...: Professor of Pharmaceutical Technology and Legislation (CHIM 09)
2010 – …...: School of Hospital Pharmacy – Director
2012 - ……: Advanced training course of pharmaceutical logistics – Director
2013 - ……: the National Conference of Directors of Schools of spec. in Hospital Pharmacy - Vice-president.
2016- ……: the National Conference of Directors of Schools of spec. in Hospital Pharmacy - President.
Teaching
Office hours
appointment by e-mail
Research
Scientific Activities
The scientific research is currently focused on:
- the study and deepening of the mechanisms underlying the wet granulation process in particular this could be useful in order to develop new scale-up strategies. Scale-up of any pharmaceutical process is a great technical and economic challenge and the current approach based on dimensionless numbers is not effective consequently the development of new strategies, e.g. the creation of new dimensionless numbers based on material properties not considered yet and easy to calculate, could represent a challenge. Granulation process and scale-up studies are performed in collaboration with the Dept. of Industrial Engineering of the University of Padova.
- the design and development of oral solid dosage forms for active molecules (synthetics and naturals as well) having problems of poor bioavailability. In this context different approaches could be used such as lipidic formulations (emulsions, microemulsions, self-emulsfying systems, etc..) and solid dispersions. The selection of the most appropriate strategy depends on the different parameters for instance physico-chemical properties of the active molecule (solubility, permeability, …) and final dosage form. This activity is also developed in collaboration with other national research groups (University of Trieste and University of Bologna) and local food supplements industries.
- the galenic clinical studies. To meet clinic requirements for individual therapeutic needings the study of galenic dosage forms is carried out to develop both semisolid ointments for topical administration and liquid or solid dosage forms fro oral administration. In any case, the research is focused on the development of suitable formulations taking into account the desired drug availability, the technological characteristics and stability of the designed formulation.
- the production procedures for industrial and extemporaneous radiopharmaceuticals, quality controls and required documents, regulatory affairs.
- the in vitro ed in vivo immunodiagnostic and drug delivery
- the pharmaceutical legislation about Italian and European legislation on pharmaceutical topics.
Technical expertise
Particles size measurement of powders, granules and emulsions: sieve analysis, image analysis and laser light scattering analysis
Other powder characterizations: flowability (shear cell test), shape (image analysis), igroscopicity (Humidity box and gravimetric analysis)
Viscosity measurement of liquid and semisolid
Granulations processes: high and low shear granulations
Tableting
Technological characterizations of oral solid dosage forms: friability, crushing strength, dissolution test
Other technological characterizations of oral solid dosage forms: tensile test, swelling ability (by image analysis)
Design of Experiments technique applied to screening of variables and formulation.
Publications
- Franceschinis E., Santomaso A.C., Benda L., Perissutti B., Voinovich D., Realdon N., Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation, 2015, Powder Technology, vol. 274 Pages 173-179. IF 2.349
- Nalesso S., Codemo C., Franceschinis E., Realdon N., Artoni R., Santomaso A.C., Texture analysis as a tool to study the kinetics of wet agglomeration processes, 2015, International Journal of Pharmaceutics, Vol 485 Pages 61-69. IF 3.650
- Franceschinis E., Santomaso A.C., Trotter A., Realdon N., High shear mixer granulation using food grade binders with different thickening power, 2014, Food Research International Vol. 64, Pages 711-717. IF 2.818 Q1
- Cavinato, M., Andreato, E., Bresciani, M., Pignatone, I., Bellazzi, G., Franceschinis, E., Realdon, N., Canu, P., Santomaso, A.C., Combining formulation and process aspects for optimizing the high-shear wet granulation of common drugs, 2011, International Journal of Pharmaceutics Vol. 416, Pages 229-241. IF 3.350 Q1
- Bigini P., Previdi S; Casarin S., Silvestri D., Violatto MB., Facchin S., Sitia L.; Rosato A., Zuccolotto G., Realdon N., Fiordaliso F., Salmona M., Morpurgo M., In Vivo Fate of Avidin-Nucleic Acid Nanoassemblies as Multifunctional Diagnostic Tools, 2014, ACS NANO, Vol. 8 (1), Pages 175-187. IF 12.881
Research projects and Funds
2005 Study of in vitro pharmaceutical equivalence of topical formulations of Betamethasone
2005 Study of in vitro pharmaceutical equivalence of topical formulations of Betamethasone
2006 Prin 2006
2006 Study of in vitro pharmaceutical equivalence of topical formulations of Sulfadiazine Ag
2008 Study of in vitro pharmaceutical equivalence of topical formulations of Diclofenac
2011 Study of in vitro pharmaceutical equivalence of topical formulations of Betamethasone
2011 Study of in vitro pharmaceutical equivalence of topical formulations of Mupirocine
2012 Study of in vitro pharmaceutical equivalence of Lithim carbonate Tablets
