Monica Montopoli
Department of Pharmaceutical and Pharmacological Sciences, University of Padova
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Short CV
2019-present Associate Professor of Pharmacology (BIO/14)
2008-2019 Assistant professor of Pharmacology (BIO/14).
She obtained her master degree in Pharmaceutical Chemistry and Technology on 2003 (University of Padova). She received her PhD in Molecular and Cellular Pharmacology in 2007, international collaboration with University of Padova, Leopold-Franzens Universitat, Innsbruck e Albert-Ludwigs Universitat, Freiburg.
Doctoral dissertation “Effect of natural and semisynthetic phenols and nuclear magnetic resonance approach in human ovarian cancer cell lines”. She has published over 40 peer-reviewed articles and over 85 abstracts in national and international conferences.
Teaching
Office hours
Tuesday, from 09:00 to 10:00
Research
Scientific Activities
Current research interests
Cellular and molecular pharmacology.
- Metabolomic profile and mitochondrial function of tumor cell :mechanisms of anti-cancer drug action/toxicity and resistance
- Chemioprevention strategies and cell cycle-protein regulators (cyclin, cdks etc.), apoptosis, transcription factors (NFkb, b-catenin),
- Oxidative stress-mediated injury in cell models of neurodegenerative/genetic disorders and pharmacological rescue.
Member Society
Società Italiana di Farmacologia (SIF)
Società Italiana di Fitoterapia (SIFIT)
Società Italiana di Citometria (GIC)
Research Collaborations:
Chemotherapy resistance and Cancer metabolism: -Cancer Cell Unit Hutchison/MRC Research Centre Cambridge UK, lOR Institute of Oncology Research -Research Division of the Oncology Institute of Southern Switzerland (IOSI) Switzerland, Department of Chemical Sciences, Biomedical Sciences and IOV ,University of Padua. Dip.Scienze Mediche e Chirurgiche - DIMEC University of Bologna, , Bologna, Italy. Pharmacological targets in neurological diseases:-IRCCS “E. Medea”, “La nostra Famiglia” Conegliano (TV) -Istituto Italiano di Tecnologia Genova (IIT) -Department of Neurological Sciences, University of Bologna, , Bologna, Italy- Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Italy
Technical expertise
Cell cultures : primary endothelial, mioblast and fibroblast and cancer cell lines. Stabilization, cybridation process and cellular trasfection. In vitro models of hypoxia and oxidative stress/inflammation. Flow cytometry, staining procedures and confocal microscopy. Western blotting. Immunoassay. Molecular biology methods (RT-PCR etc) and magnetic resonance 1H-NMR techniques applied to metabolomic studies.
Publications
Giordano C1, Montopoli M1, Perli E, Orlandi M, Fantin M, Ross-Cisneros FN, Caparrotta L, Martinuzzi A, Ragazzi E, Ghelli A, Sadun AA, d'Amati G, Carelli V. Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy. Brain. 2011 Jan;134(Pt 1):220-34. 1 These authors contributed equally to this work I.F. 10.418 Q1
Catanzaro D, Gaude E, Orso G, Giordano C, Guzzo G, Rasola A, Ragazzi E, Caparrotta L, Frezza C, Montopoli M. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death. Oncotarget. 2015 Oct 6;6(30):30102-14. I.F. 6.368 Q1
Catanzaro D, Rancan S, Orso G, Dall'Acqua S, Brun P, Giron MC, Carrara M, Castagliuolo I, Ragazzi E, Caparrotta L, Montopoli M. Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. PLoS ONE. 2015 10(5): e0125375 I.F. 3.702 Q1
Pisano A, Preziuso C, Iommarini L, Perli E, Grazioli P, Campese AF, Maresca A, Montopoli M, Masuelli L, Sadun AA, d'Amati G, Carelli V, Ghelli A, Giordano C. Targeting estrogen receptor β as preventive therapeutic strategy for Leber's hereditary optic neuropathy. Hum Mol Genet. 2015 Dec 15;24(24):6921-31. I.F. 6.850 Q1
