Marisa Dal Zotto
Department of Pharmaceutical and Pharmacological Sciences, University of Padova Contacts |
Short CV
1981: Degree summa cum laude in Pharmacy, University of Padova
1983-1986: PhD in Pharmaceutical Technology, Dept of Pharmaceutical Sciences, University of Padova (Supervisor: Prof. Enrico Ragazzi)
1988: Specialisation degree summa cum laude in Hospital Pharmacy
1987-1988: Hospital Pharmacist, ULSS n. 4 Alto Vicentino – Regione Veneto
1989-present: Researcher and Assistant Professor of Pharmaceutical Technology (SSD CHIM/09)
Teaching
Office hours
by appointment only
Research
Scientific Activities
The research activity is focused on
Development of controlled release from oral dosage forms
The research is concerning the development of swellable matrices obtained by direct compaction of powder mixtures. The matrix formulation is to be assessed to obtain both the desired drug availability and the tablet suitable technological characteristics. Drug availability is tested by evaluation of its dissolution performance in different conditions and the tablet technological characteristics are determined by different tests (crushing strength, friability, etc.). The study is focused on the effect both of the excipients and of the medium composition on the course and mechanism of drug dissolution from the matrix.
Development of galenic preparations for galenic clinic
To meet clinic requirements for individual therapeutic needings the study of galenic dosage forms is carried out to develop both semisolid ointments for topical administration and liquid or solid dosage forms fro oral administration. In any case, the research is focused on the development of suitable formulations taking into account the desired drug availability, the technological characteristics and stability of the designed formulation.
Studies on suppositories
The research activity is focused on the development of formulations using surfactants. In particular, the effects of surfactants on drug availability and on the release mechanisms are evaluated, based on tensiometric and rheological methods.
Studies on pharmaceutical legislation
In addition to research activities studies are carried out about Italian and European legislation on pharmaceutical topics.
Technical expertise
- formulation of solids, semisolids
- technological testing of powders and solid dosage forms (powders flowability, tablets crushing strength, friability)
- drug availability from solid dosage forms (disaggregation, dissolution testing in different conditions from tablets, ointments and suppositories)
- tableting
- viscosity of liquid and semisolid fluids
Publications
2013. The effect of drug solubility and of filler characteristics onthe release control from HPMC-tablets. pp.156. In Programme and Abstracts 3rd conference on Innovation in Drug Delivery: Advances in Local Drug Delivery, Pisa (Italy)
Dal Zotto Marisa; Franceschinis Erica; Realdon Nicola
2012. Effect of the surfactant on the availability of piroxicam as a poorly hydrosoluble drug from suppositories. DOI:10.1691/ph.2012.1092. pp.37-45. In PHARMAZIE - ISSN:0031-7144 vol. 1
DAL ZOTTO M; FRANCESCHINIS E; PUNCHINA A; N. REALDON IF 0,962, Q2
2011. Self-emulsifying pellets in a lab-scale high shear mixer: Formulation and production design. pp.113-118. In POWDER TECHNOLOGY - ISSN:0032-5910 vol. 207
E. FRANCESCHINIS; C. BORTOLETTO; B. PERISSUTTI; M. DAL ZOTTO; D. VOINOVICH; N. REALDON IF 2,080, Q2
2008. The effects of surfactant characteristics on drug availability from suppositories. pp.459-463. In PHARMAZIE - ISSN:0031-7144 vol. 63
N. REALDON; M. DAL ZOTTO; M. MORPURGO; FRANCESCHINIS E. IF 0,858, Q3
