Our research aims to investigate new approaches of drug conjugation to mAb and the potential of new hydrophilic linkers able to counterbalance the common high hydrophobicity of drugs, thus allowing higher drug payload.
Tedeschini T, Campara B, Grigoletto A, Bellini M, Salvalaio M, Matsuno Y, Suzuki A, Yoshioka H, Pasut G. Polyethylene glycol-based linkers as hydrophilicity reservoir for antibody-drug conjugates. J Control Release. 2021;337:431-447. doi: 10.1016/j.jconrel.2021.07.041.
Maso K, Montagner IM, Grigoletto A, Schiavon O, Rosato A, Pasut G. A non-covalent antibody complex for the delivery of anti-cancer drugs. Eur J Pharm Biopharm. 2019;142:49-60. doi: 10.1016/j.ejpb.2019.06.012
