Guglielmina Froldi
 | Department of Pharmaceutical and Pharmacological Sciences, University of Padova |
Short Cv
1984: Degree summa cum laude in Pharmacy, University of Padova.
1986-1990: Doctorate in Pharmacology and Toxicology, Department of Pharmacology, University of Padova, Supervisor: Prof. Giuliana Fassina.
1989: Exchange PhD. Student, Cardiovascular laboratory, Department of Pharmacology-Division-JHMHC Cardiology, University of Florida (USA), Supervisor: Prof. Luiz Belardinelli
1991-1992: Post-Doc, Department of Pharmacology, University of Padova, Supervisor: Prof. Giuliana Fassina.
1992: Assistant Professor of Pharmacology (SSD BIO/14), Department of Pharmacology, University of Padova.
2006-present: Associate Professor of Pharmacology (SSD BIO/14, now disciplinary area code 05/G1), Department of Pharmaceutical and Pharmacological Sciences, University of Padova.
Teaching
Office hours
Monday to Friday: 9.00 a.m. - 11.00 a.m.
Availability for Thesis Projects
Study of traditional medicinal plants and isolated constituents regarding their actions on cardiovascular system and aging-related diseases. Furthermore, pharmacological transduction mechanisms are always evaluated with interest.
Research
Scientific Activities
The research experience is mainly focused on medicinal plants of traditional use and isolated phytoconstituents, mainly on cardiovascular system. The scientific activity is documented by more than 65 manuscripts published extensively in international journals for the most part, 65 proceedings and more than 120 participations in national and international conferences. The publishing activity also consists of 10 chapters about topics of Pharmacognosy, Pharmacology and Toxicology.
The main lines of research are:
1. Study of plants traditionally used for hypoglycaemic, hypotensive, antiviral and healing properties (i.e. Croton spp., Casimiroa spp., Pterodon emarginatus, etc.).
2. In vitro determination of the antioxidant capacity of plant extracts and natural compounds.
3. In vitro cellular uptake assessment of natural compounds as a prediction tool of in vivo bioavailability.
Technical expertise
DPPH assay; ORAC assay; Total Phenolic Content (TPC) assay; Total flavonoids Content (TFC) assay; Phytochemical screening by HPLC-DAD; Human Umbilical Vein Endothelial Cells (HUVEC) protocols; human ox-LDL protocols; cellular uptake protocols; Advanced Glycation End-products (AGEs) determination.
Publications
1. R. Bertin, Z. Chen, M. Martínez-Vázquez, Aída N. García-Argáez, Guglielmina Froldi* (2014). Vasodilation and radical-scavenging activity of imperatorin and selected coumarinic and flavonoid compounds from genus Casimiroa. Phytomedicine, vol. 21, p. 586-594, ISSN: 0944-7113, doi: 10.1016/j.phymed.2013.10.030. -Impact Factor 2.877 Q1
2. Zheng Chen, Riccardo Bertin, Guglielmina Froldi* (2013). EC50 estimation of antioxidant activity in DPPH. assay using several statistical programs. Food Chemistry, vol. 138, p. 414-420, ISSN: 0308-8146, doi: 10.1016/j.foodchem.2012.11.001 -Impact Factor 3.334 Q1
3. Monica Montopoli, Riccardo Bertin, Zheng Chen, Jenny Bolcato, Laura Caparrotta, Guglielmina Froldi* (2012). Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines. Journal of Ethnopharmacology, vol. 144, p. 747-753, ISSN: 0378-8741, doi: 10.1016/j.jep.2012.10.032 -Impact Factor 2.755 Q1
4. Guglielmina Froldi*, Bertin R, Secchi E, Zagotto G, Martinez-Vazquez M, Garcia-Argaez A (2011). Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms. Journal of Ethnopharmacology, vol. 134, p. 637-643, ISSN: 0378-8741, doi: 10.1016/j.jep.2011.01.008 -Impact Factor 3.014 Q1- V. 100
Research projects and Funds
2013-2015: Ex 60% Projects, University of Padova, 6921 € - PI. “Anti-AGEs activity of plant extracts and natural compounds”. 60A04-3528/13, 60A04-8109/14, 60A04-9330/15
2011- 2012 PRA Project, University of Padova, 35100 €, PI. “Pharmacological activity of herbal drugs of traditional use: antioxidant activity and characterization of Croton lechleri and its phytoconstituents." CPDA111257/11.
