Giorgia Miolo
 | Department of Pharmaceutical and Pharmacological Sciences, University of Padova Position Contacts |
Short CV
Born in Padua, Italy, March 12th 1959.
1984, Laurea summa cum laude in Pharmaceutical and Technological Chemistry at the University of Padua.
1984 - 1985, fellow at the Department of Pediatrics of the University of Padua
1985-1988, fellow PhD in Pharmaceutical Sciences at the Department of Pharmaceutical Sciences in Padua:
1985 - 1986, visiting research scientist at the Department of Dermatology, Yale University, New Haven, US.
1987, visiting research scientist at the Institute Curie, Section de Biologie, Paris, France
1989, Doctor in Pharmaceutical Sciences (Ph.D)
1989, Researcher at the Department of Pharmaceutical Sciences of Padua University
2006, Associate Professor at the Department of Pharmaceutical Sciences of Padua University
She is the President of the Italian Society of Photobiology (SIFB) since 2012,
2011, Treasurer of Italian Society of Photobiology, Società Italiana di Fotobiologia (SIFB) member of the European Society for Photobiology (ESP), member of the CRS Controlled Drug Release Italy Chapter.
Teaching
Office hours
Monday to Friday, 10-12 am, 15.00 -17.00 by appointment (giorgia.miolo@unipd.it or tel. 049-8275705), at the Department of Pharmaceutical and Pharmacological Sciences, via Marzolo 5, Padova
Research
Scientific Activities
Research activity
Since many years involved in the studies on mechanistic aspects of furocoumarins and analogues in PUVA therapy and on the photoinduced drug toxicity and photostability. Recently, she has focused her research on the transformation of illicit drugs by solar light and selected UVA-UVB irradiation, and the products of photodecomposition of CNS drugs for the search of new markers of drug toxicity in hair and new pollutants in waters.
In particular: a) study of the UVA photointeractions of some phototherapeutic agents with biological substrates (DNA, proteins and lipids); b) in vitro drug phototoxicity studies : mechanisms of the photosensitizing reactions induced by drugs under UVA-UVB light and solar light; c) photostability studies: photolysis of medicines and additives in vitro (in solution and in pharmaceutical formulation) and of of illicit drugs, characterization of the photoproducts formed under irradiation, their role in the photosensitizing activity and loss of therapeutic activity and new markers of drug abuse.
Other tasks
2009, 2010, 2011, Local Organizer of the Summer School: “Patient safety, pharmacovigilance and toxicology: the role of the Pharmacist”; “Pharmaceuticals and drug misuse: clinical and toxicological issues” “Drug use, misuse and dependence; the clinical role of the pharmacist”, between the Faculties of Pharmacy of Padova University and Hertfordshire University (UK)
2012, Local Organizer of the Annual Meeting of SIFB in Padova, June 14-16
2014, Local Organizer of the 3rd ESP International Photobiology School, Brixen, 16-21 June, 2014
2016, Local Organizer of the 4th ESP International Photobiology School, Brixen, June 20-25 2016
Main lectures
Meccanismi farmacologici e fotobiologici nella fototossicità da farmaco, Congresso Nazionale SIDeMaST, Lido di Venezia, 2013;
Photostability of illict drugs in different matrices, ESP conference Liege, Belgium, 2013,
Drug- photosensitised modifications of proteins, 3rd Joint Meeting of the French Society for Photobiology and the Italian Society for Photobiology, 2010, Paris;
Effects of UVB light on antiinflammatory corticosteroids in different experimental models,12th ESP Congress, Bath-UK, 2007.
Experience abroad
1986 (6 months), visiting research scientist at the Department of Dermatology, Yale University, New Haven, USA;
1987 (6 months), visiting research scientist at the Institute Curie, Section de Biologie, Paris, France.
Technical expertise
The experimental activity is focused on photobiology and photochemistry issues: the photoreactivity of drugs/illicit drugs and biological active compounds under selected wavelengths (UVA and UVB lamps) and solar light (sunlight simulator) in different matrices (solid, organic, aqueous solution, formulations) isolation and characterization of photoadducts with target substrates (salmon testes, calf thymus, plasmid- DNA, lipids, proteins, amino acids) and photodegradation products (UV-Vis spectroscopy, LD-linear dichroism (DNA intercalating agents), Solid-Liquid chromatography (TLC, HPLC, UPLC), MS spectrometry (HRMS), DNA electrophoresis, studies of phototoxic and photo-antiproliferative activity of compounds on human normal or tumour cell cultures.
Publications
- Dalla Via Lisa, Marzaro Giovanni, Mazzoli Alessandra, Chilin Adriana, Miolo Giorgia (2015). Photobiological properties of 3-psoralenacetic acids. Photochemical and Photobiological Sciences, vol. 14, p. 2074-2086, ISSN: 1474-905X, doi: 10.1039/c5pp00210a
- Favretto D, Tucci M, Monaldi A, Ferrara SD, Miolo G (2014). A study on photodegradation of methadone, EDDP, and other drugs of abuse in hair exposed to controlled UVB radiation. Drug Testing and Analysis, vol. 6 Suppl 1, p. 78-84, ISSN: 1942-7603, doi: 10.1002/dta.1607 Impact Factor 2.816 Q2
- Giorgia Miolo, Alessia Salvador, Alessandra Mazzoli, Anna Spalletti, Giovanni Marzaro, Adriana Chilin (2014). Photochemical and photobiological studies on furoquinazolines as new psoralen analogs. Journal of Photochemistry and Photobiology B-Biology, vol. 138, p. 43-54, ISSN: 1011-1344, doi: 10.1016/j.jphotobiol.2014.05.002 Impact Factor 2.803 Q2
- G. MIOLO, Caffieri S, Dalzoppo D, Gallocchio F, Fasani E, Beyersbergen Van Henegouwen Gm (2011). Photoactivation of corticosteroids in UVB-exposed skin.. Journal of Photochemistry and Photobiology B-Biology, vol. 103, p. 35-41, ISSN: 1011-1344, doi: 10.1016/j.jphotobiol.2011.01.009
- G. Miolo, Marzano C., Gandin V., Palozzo A. C., Salvador A., Dalzoppo D. and Caffieri S. (2011). Photoreactivity of 5-Fluorouracil under UVB light: Photolysis and Cytotoxicity Studies. Chemical Research In Toxicology, vol. 24(8), p. 1319-1326, ISSN: 0893-228X, doi: 10.1021/tx200212z
Research projects and Funds
He took part in several research programs at the national (PRIN) and local (ex 60% and PRAT) levels.
PRIN 2010-11 Proprietà fotofisiche e fotochimiche di composti organici e di interesse biologico in soluzione e in sistemi organizzati (P). PRIN 2008 Fotochimica e fotofisica di pigmenti fotosintetici e di composti ad uso farmaceutico (P).PRIN 2002 Fotoprocessi che influenzano l'attività di farmaci e il trasferimento di carica e/o energia nei sistemi coniugati (P).PRIN 2000 Relazione tra struttura chimica e fotoreattività di arilpolieni e farmaci in sistemi organizzati (P).PRIN 1998 Studio di processi fotofisici e fotochimici coinvolgenti arilpolieni e farmaci (P).PRIN 1997 Progettazione, sintesi e studio di agenti chemio e fotochemioterapici (P).
2006 – 2013, 2015: Ex 60% Projects, University of Padova, 40.000 euro - PI.
""Fotoreattività di farmaci e di composti di origine naturale biologicamente attivi"
2011 – 2015. “Stabilità e fotostabilità di una nanoemulsione (nanogel) contenente 5-ALA Ditta Labomar Srl. euro 7.500,00 - PI.
2015, Progetti di Ricerca di Ateneo – Area 4, Codice progetto: CPDA150854- Effectiveness of photoactivatable drugs on prostate cancer stem cells: a pilot study € 42.168,00
