Erica Franceschinis

Department of Pharmaceutical and Pharmacological Sciences, University of Padova
via F. Marzolo 5, 35131 Padova - Italy

Current Position:
Assistant professor of 
Galenic Formulation and Legislation (CHIM09) 

Contacts
Phone: +39-049-827-5339
Fax:  +39-049-827-5366
e-mail: erica.franceschinis@unipd.it
Skype: e.franceschinis

2001: Degree in Pharmaceutical Chemistry and Technology at the University of Trieste (Italy)

2002-2005: Ph.D. in Engineering and Science of Materials at the University of Trieste (Italy) (Supervisor: Prof Dario Voinovich)

2005-2007: Pharmacist at Farmacia alla Borsa (Trieste, Italy)

2007-present: Assistant professor of Galenic Formulation and Legislation (CHIM 09)

Teaching

by appointment

Research 

Agglomeration mechanisms and scale-up

The scientific research is currently focused on the study and deepening of the mechanisms underlying the wet granulation process in particular this could be useful in order to develop new scale-up strategies. Scale-up of any pharmaceutical process is a great technical and economic challenge and the current approach based on dimensionless numbers is not effective consequently the development of new strategies, e.g. the creation of new dimensionless numbers based on material properties not considered yet and easy to calculate, could represent a challenge. Granulation process and scale-up studies are performed in collaboration with the Dept. of Industrial Engineering of the University of Padova.

Design and development of oral solid dosage forms

Another branch of research activity is focused on the on design and development of oral solid dosage forms for active molecules (synthetics and naturals as well) having problems of poor bioavailability. In this context different approaches could be used such as lipidic formulations (emulsions, microemulsions, self-emulsfying systems, etc..) and solid dispersions. The selection of the most appropriate strategy depends on the different parameters for instance physico-chemical properties of the active molecule (solubility, permeability, …) and final dosage form. This activity is also developed in collaboration with other national research groups (University of Trieste and University of Bologna) and local food supplements industries.

Dispersion Improvement of hydrophilic powders

A new research is constituted by the development of techniques and strategies to improve the dispersion of high hydrophilic molecules such as hydrocolloids used both in food and pharmaceutical industries mainly as thickeners and binders.

Particles size measurement of powders, granules and emulsions: sieve analysis, image analysis and laser light scattering analysis

Other powder characterizations: flowability (shear cell test), shape (image analysis), hygroscopicity (humidity box and gravimetric analysis)

Viscosity measurement of liquid and semisolid

Rheology of the wet masses

Granulations processes: high and low shear granulations

Tableting

Technological characterizations of oral solid dosag

e forms: friability, crushing strength, dissolution test

Other technological characterizations of oral solid dosage forms: tensile test, swelling ability (by image analysis)

Design of Experiments technique applied to screening of variables and formulation.

  1. Franceschinis E., Santomaso A.C., Benda L., Perissutti B., Voinovich D., Realdon N., Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation, 2015, Powder Technology, vol. 274 Pages 173-179. IF 2.349
  2. Nalesso S., Codemo C., Franceschinis E., Realdon N., Artoni R., Santomaso A.C., Texture analysis as a tool to study the kinetics of wet agglomeration processes, 2015, International Journal of Pharmaceutics, Vol 485 Pages 61-69. IF 3.650
  3. Franceschinis E., Santomaso A.C., Trotter A., Realdon N., High shear mixer granulation using food grade binders with different thickening power, 2014, Food Research International Vol. 64, Pages 711-717. IF 2.818 Q1
  4. Passerini, N., Perissutti, B., Albertini, B., Franceschinis, E., Lenaz, D., Hasa, D., Locatelli, I., Voinovich, D., A new approach to enhance oral bioavailability of Silybum Marianum dry extract: Association of mechanochemical activation and spray congealing, 2012, Phytomedicine Vol. 19 Pages 160-168. IF 2.972 Q1
  5. Cavinato, M., Andreato, E., Bresciani, M., Pignatone, I., Bellazzi, G., Franceschinis, E., Realdon, N., Canu, P., Santomaso, A.C., Combining formulation and process aspects for optimizing the high-shear wet granulation of common drugs, 2011, International Journal of Pharmaceutics Vol. 416, Pages 229-241. IF 3.350 Q1

2015-2016: PRAT 2015 (Progetti di Ricerca di Ateneo) (Prot. CPDA158924), University of Padova, Dept. of Industrial Engineering Dispersion Improvement of Dehydrate Food in Water, 25.000 euro – RUC

2013-2015 Development of oral and topical sucrose esters-based formulations for the delivery of lipophilic molecules Labomar srl (Istrana, TV, Italy) Supervisor. Research Grant for a PhD Program in Molecular Sciences (Dottorato in Alta Formazione), University of Padova.