Alessandro Dolmella
 | Department of Pharmaceutical and Pharmacological Sciences, University of Padova Contacts |
Short CV
Born in Udine on 15.11.62
1985: Degree summa cum laude in Pharmacy, University of Padua
1988: One-year research Grant from ICI-Pharma at Alderley Park, Cheshire, UK
1989: One-year research Grant from Industria Farmaceutica Ravizza s.p.a. c/o Dept. of Pharmaceutical Sciences, Padua University
Nov. 1989: Visting Scientist c/o University of Lausanne (CH), c/o Prof. Bernard Testa’s laboratory
1992-1993: Visting Scientist c/o Farmitalia Carlo Erba Research Park in Nerviano (MI), Italy, c/o Prof. G. Bolis' laboratory
1990-2006: Assistant Professor of General Inorganic Chemistry (SSD: CHEM-03/A)
2006-present: Associate Professor of General Inorganic Chemistry (SSD: CHEM-03/A)
Teaching
General and Inorganic Chemistry in both single-cycle Master's degree courses in Pharmacy and Pharmaceutical Chemistry and Technology.
Office hours
Monday to Friday in the afternoon, usually 15:30 - 16:30, if not involved in other duties.
Students must fix an appointment by e-mailing or phone calling (see fundamental information in Teacher's page).
Availability for Thesis Projects (in ITALIAN)
Argomento generale delle Tesi Sperimentali: Sintesi, caratterizzazione chimico - fisica di farmaci e radiofarmaci a base metallica.
La disponibilità di spazi di ricerca limitati restringe l'accoglienza a un numero massimo di due internisti contemporaneamente presenti. Studenti interessati a futuri internati di tesi devono contattare il Docente, preferibilmente via e-mail, per concordare un appuntamento in presenza.
NOTA BENE: Non si calendarizzano le immissioni all'internato, ma l'accesso è regolato sulla base del 'first come, first taken'.
General Topic for Experimental Theses: Synthesis, physico-chemical characterization of metal-based drugs and radiopharmaceuticals.
The research labs are placed in small rooms, so that it is impossible to host more than two internship Students in a given time window. Students must e-mail the Teacher to know more and book an interview.
NOTICE: In this research group we don't book in advance internships slots; the access is granted on the basis of 'first come, first taken'.
Argomenti per Tesi Compilative possono essere resi disponibili occasionalmente, secondo la disponibilità di materiale pertinente (vedi testo seguente).
Topics for non-experimental Theses may be available from time to time (see text below).
i) Sono stati resi disponibili al Docente dei materiali per possibili Tesi Compilative nel CdLM in FARMACIA aventi come oggetto la raccolta, la sistematizzazione e la classificazione di una certa mole di dati di assistenza clinica ad un portatore di malattia di Alzheimer, rilevanti dal punto di vista farmacoeconomico, clinico, dell'uso di medical devices.
i) Materials have been made available to the Teacher for possible non-experimental Theses in the Degree Course in PHARMACY having as object the collection, systematization and classification of a certain amount of clinical care data for a patient suffering with Alzheimer's disease, relevant from the pharmacoeconomic, clinical and use of medical devices points of view
ii) Si può valutare la possibilità di utilizzare parte del materiale per sostanziare anche una Tesi Sperimentale nel CdLM in FARMACIA, avente come oggetto la validazione di un prototipo di medical device per la somministrazione in regime di osmolarità controllata di soluzioni complesse destinate alla nutrizione di pazienti portatori di stomia. Il prototipo consente di controllare il flusso e la viscosità in uscita in uscita della miscela complessa. La misura dei dati sperimentali dovrà avvenire in collaborazione con altri Docenti.
ii) The possibility of using part of the material to support an experimental thesis in the Master's Degree in PHARMACY may be considered. In this case, the thesis will focus on validating a prototype medical device for the controlled-osmolarity administration of complex solutions intended for the nutrition of patients with stomas. The prototype allows for the control of the flow rate and output viscosity of the complex mixture. Measurement of the experimental data will be performed in collaboration with other Teachers.
Gli Studenti interessati sono pregati di prendere contatto con il Docente.
Interested Students must contact the Teacher.
Research
Coordination Chemistry.
Bioinorganic chemistry of metals of Groups 7, 11 (and others) of PT.
Radiopharmacy of metal-based SPECT and PET imaging/therapeutics/Theranostics agents.
Computational Chemistry.
Chemical Crystallography.
Scientific Activities
Research activity
Synthesis and structural investigation of new relevant bioinorganic coordination compounds based on transition metals (mainly of Groups 7, 11) via single crystal (and occasionally powders) X-ray diffractometry; synthesis and physico-chemical characterization of metal-based radiopharmaceuticals (both radiodiagnostics and radiotherapics) harboring radionuclides mainly (but not exclusively) belonging to Groups 7, 11, 13, with special emphasis on brain, hearth and tumor imaging. Other interests involve modelling as well as investigation of conformational and electronic properties of compounds via semiempirical, HF and DFT calculations; SAR e QSAR analysis; further X-ray diffractometry analyses. Ultimate goal: development of bioinorganic compounds for clinical applications.
Services to the Community
Embodied in the Referee panel for the journals Inorganica Chimica Acta, Polyhedron, Inorganic Chemistry Communications, Journal of Molecular Structure, European Journal of Medicinal Chemistry.
Memberships
Member of the Italian Chemical Society (S.C.I.); member of Italian Crystallography Association (A.I.C.).
Governance
Institutional committees (C.C.S. Pharmacy, C.C.S. Pharmaceutical Chemistry and Technologies, Council of Department); member of the Resources and Development Commission of the Department of Pharmaceutical and Pharmacological Sciences (Coordinator: Prof. C. Sissi).
Technical expertise
Crystallography of transition metal/organometallic/inorganic coordination complexes; design, synthesis, physico-chemical and biological characterization of metal-based radiopharmaceuticals; radiolabelling of biologically relevant compounds; biodistribution studies of radiopharmaceuticals; molecular imaging.
Computational chemistry of small molecules at empirical, semi-empirical, HF and DFT level.
Especially relevant facilities
Single-crystal (and potentially powders), ‘Enhance’ double-source Mo and Cu four-circle (kappa geometry) CCD area detector X-ray diffractometer Gemini EOS (Rigaku/Oxford Diffraction); date of installation: end of 2009 (fundings: 2008 University budget for large instrumentation); beginning of activity: 2010; CCD EOS detector replaced with an ATLAS one in 2024 by the generous help of Prof. Kari Rissanen University of Jyväskylä, Finland.
Positions available
Under the term 'positions' are indicated PhD, Post-Doc or any kind of grant. Availability: None to date
Publications
Latest most relevant publication:
New Synthesis and Pharmacological Evaluation of Enantiomerically Pure (R)- and (S)-Methadone Metabolites as N-Methyl-d-aspartate Receptor Antagonists
Marco Banzato, Alberto Furlan, Patrizia Locatelli, Jacopo Sgrignani, Alberto Ongaro, Alessandro Dolmella, Sara De Martin, Stefano Comai, Andrea Cavalli, Charles Inturrisi, Ezio Bettini, Paolo L. Manfredi, Andrea Mattarei
Journal of Medicinal Chemistry, 2025, 68, 5, 5455–5470
Patents
None to date.
Research projects and Funds
General:
2015-present: DOR projects fundings, University of Padova, Department of Pharmaceutical and Pharmacological Sciences, total < 2.000 euro/year.
Specific:
PRID 2022 (as participant) project entitled: "TheranosticCopper Complexes in Prostate Cancer (THERACuPROST)". Total Budget: 30.000 euros.
