Short CV

Born in Udine on 15.11.62 

1985: Degree summa cum laude in Pharmacy, University of Padua

1988: One-year research Grant from ICI-Pharma at Alderley Park, Cheshire, UK

1989: One-year research Grant from Industria Farmaceutica Ravizza s.p.a. c/o Dept. of Pharmaceutical Sciences, Padua University

Nov. 1989: Visting Scientist c/o University of Lausanne (CH), c/o Prof. Bernard Testa’s laboratory

1992-1993: Visting Scientist c/o Farmitalia Carlo Erba Research Park in Nerviano (MI), Italy, c/o Prof. g. Bolis' laboratory

1990-2006: Assistant Professor of General Inorganic Chemistry (SSD: CHIM03)

2006-present: Associate Professor of General Inorganic Chemistry (SSD: CHIM03)

  Courses

Educational offer

  Office hours

Monday to Friday in the afternoon: 16:00 - 17:00.

Students coming from outside town should fix an appointment by e-mail or phone calling.

 

  Availability for Thesis Projects (in ITALIAN)

Argomento generale delle Tesi Sperimentali: Sintesi e caratterizzazione di farmaci e radiofarmaci a base metallica.

La disponibilità di spazi di ricerca limitati restringe l'accoglienza a un numero massimo di due internisti contemporaneamente presenti. Scrivere o telefonare al Docente per ulteriori dettagli. Per l'a.a. 2019-2020 gli spazi sono già saturati; Studenti interessati a futuri internati di tesi devono prendere contatto con il Docente a fine estate 2020.

NOTA BENE: Non si calendarizzano le immissioni all'internato, ma l'accesso è regolato sulla base del 'first come, first taken'.

Argomenti per Tesi Compilative possono essere resi disponibili di volta in volta, secondo la disponibilità di materiale pertinente.

Ottobre 2019: Sono stati resi disponibili al Docente dei materiali per possibili Tesi Compilative nel CdLM in FARMACIA aventi come oggetto la raccolta, la sistematizzazione e la classificazione di una consistente mole di dati di assistenza clinica ad un portatore di patologia di Alzheimer, rilevanti dal punto di vista farmacoeconomico, clinico, dell'uso di medical devices. 

Febbraio 2020: Come ulteriore possibile variazione di quanto già sopra riportato, si può valutare la possibilità di utilizzare parte del materiale per sostanziare una Tesi Sperimentale nel CdLM in FARMACIA, avente come oggetto la validazione di un prototipo di medical device per la somministrazione in regime di osmolarità controllata di soluzioni complesse destinate alla nutrizione di pazienti portatori di stomia. Il prototipo di dispositivo consente di controllare il flusso e la viscosità in uscita in uscita della miscela complessa. La misura dei dati sperimentali dovrà avvenire in collaborazione con altri Docenti del Dipartimento.

Gli Studenti interessati sono pregati di prendere contatto con il Docente.

  Scientific Activities

Research activity
Synthesis and structural investigation of new biologically relevant bioinorganic coordination compounds based on transition metals (Groups 7, 10, 11, 13) via single crystal and powders X-ray diffractometry; synthesis and physico-chemical characterization of metal-based radiopharmaceuticals (both radiodiagnostics and radiotherapics) harboring radionuclides mainly (but not exclusively) belonging to Groups 7, 11, 13, with special emphasis on brain, hearth and tumor imaging. Other interests involve modelling as well as investigation of conformational and electronic properties of compounds via semiempirical, HF and DFT calculations; SAR e QSAR analysis and further X-ray diffractometry analyses. Ultimate goal: development of bioinorganic compounds for clinical applications. 

Services to the Community
Embodied in the Referee panel for the journals Chemical Communications, New Journal of Chemistry, Inorganica Chimica Acta, Polyhedron, Inorganic Chemistry Communications, Journal of Molecular Structure, European Journal of Medicinal Chemistry. 

Memberships
Member of the Italian Chemical Society (S.C.I.); member of Italian Crystallography Association (A.I.C.) dell’Associazione Italiana di Cristallografia; Local representative for Padua University towards the CCDC (Cambridge Crystallographic Database Center). 

Governance
Besides to institutional committees (C.C.S. Pharmacy, C.C.S. Pharmaceutical Chemistry and Technologies, Council of Department) at present Prof. Dolmella participates in the Scientific Commission of the Medicinal Chemistry Area (Coordinator: Prof. S. Moro) .

  Technical expertise

Crystallography of transition metal/organometallic coordination complexes; design, synthesis, physico-chemical and biological characterization of metal-based radiopharmaceuticals; radiolabelling of biologically relevant compounds; biodistribution studies of radiopharmaceuticals; molecular imaging.

Especially relevant facilities
Single-crystal (and potentially powders), ‘Enhance’ double-source Mo and Cu four-circle (kappa geometry) CCD area detector X-ray diffractometer Gemini EOS (Rigaku/Oxford Diffraction); date of installation: end of 2009 (fundings: 2008 University budget for large instrumentation); beginning of activity: 2010

  Positions available

  Publications

• Rossana Galassi, Camille Simon Oumarou, Alfredo Burini, Alessandro Dolmella, Daniela Micozzi, Silvia Vincenzetti, Stefania Pucciarelli (2015). A study on the inhibition of dihydrofolate reductase (DHFR) from Escherichia coli by gold(i) phosphane compounds. X-ray crystal structures of (4,5-dichloro-1H-imidazolate-1-yl)-triphenylphosphane-gold(i) and (4,5-dicyano-1H-imidazolate-1-yl)-triphenylphosphane-gold(i). DALTON TRANSACTIONS, vol. 44, p. 3043-3056, ISSN: 1477-9226, doi: 10.1039/C4DT01542H
  IF=4.197; Q1
• Nicola Salvarese, Alessandro Dolmella, Fiorenzo Refosco, Cristina Bolzati (2015). Reactivity of the [M(PS)2]+Building Block (M = ReIIIand99mTcIII; PS = Phosphinothiolate) toward Isopropylxanthate and Pyridine-2-thiolate. INORGANIC CHEMISTRY, vol. 54, p. 1634-1644, ISSN: 0020-1669, doi: 10.1021/ic502632h
  IF=4.762; Q1
• Augusto Tassan, Mirto Mozzon, Giacomo Facchin, Alessandro Dolmella, Serena Detti (2015). Synthesis, characterization and dynamic behavior of some iridium carbonyl cluster complexes derived from Ir4(CO)12 with N-, P- and C-donor ligands: A survey. INORGANICA CHIMICA ACTA, vol. 424, p. 91-102, ISSN: 0020-1693, doi: 10.1016/j.ica.2014.09.014
  IF=2.046; Q2
• V. Gandin, F. Tisato, A. Dolmella, M. Pellei, C. Santini, M. Giorgetti, C. Marzano, M. Porchia (2014). In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxilliary monodentate phosphine ligands. JOURNAL OF MEDICINAL CHEMISTRY, ISSN: 0022-2623, doi: 10.1021/jm500279x
  IF=5.480; Q1
• Marco Baron, Stéphane Bellemin-Laponnaz, Cristina Tubaro, Marino Basato, Sara Bogialli, Alessandro Dolmella (2014). Synthesis and biological assays on cancer cells of dinuclear gold complexes with novel functionalised di(N-heterocyclic carbene) ligands. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 141, p. 94-102, ISSN: 0162-0134, doi: 10.1016/j.jinorgbio.2014.08.013
  IF=3.274; Q1

  Complete list of publications

Alessandro Dolmella in Padua Research Archive IRIS (Institutional Research Information System)

  Patents

  Research projects and Funds

After 2015: only ex 60% Projects, University of Padova, ca. 6.000 euro.

2000-2015: Ex 60% Projects, University of Padova, ca. 45.000 euro (missing data) - PI.
Synthesis, characterization and structure investigation of new nootropic and bioinorganic therapeutic agents. 

2001-2002: PRIN-2001, MIUR - Italian Ministry of Scientific Research, 66.000 euro - P.
Synthesis, characterization as well as cellular and subcellular way of action of potentially chemotherapic metal complexes. 

2006-2007: PRAT Atheneum Research Project, CPDA065113, University of Padova, P.
Coordination compounds as antitumor agents: new cellular, subcellular and molecular target identification. 

2007-2008: PRIN-2007, MIUR - Italian Ministry of Scientific Research, 88.000 euro - P.
Synthesis, characterization as well as cellular and subcellular way of action of potentially chemotherapic metal complexes. 

2010-2011: Junior Research Grant CPDR102505/10, University of Padova, ca. 19.000 euro - PI.
Design, synthesis and developement of target-specific technetium and rhenium radiopharmaceuticals. 

2012-2013: PRAT Atheneum Research Project, CPDA121973, University of Padova, P.
Copper(I) complexes as protein tyrosine phosphatase (PTP) inhibitors: a new approach to antimetastatic drug discovery.