Adriana Chilin

Adriana Chilin

Department of Pharmaceutical and Pharmacological Sciences, University of Padova
via F. Marzolo 5, 35131 Padova - Italy

Position: Associate Professor of Medicinal Chemistry (SSD CHIM/08)

Contacts
Phone: +39-049-827-5349
Fax:  +39-049-827-5366
e-mail: adriana.chilin@unipd.it

  Short CV

Born in Padova on 02/08/1959


Education and Training

1983 - Degree summa cum laude in Pharmaceutical Chemistry and Technology, University of Padova

1985-1988 - PhD in Pharmaceutical Sciences, Dept of Pharmaceutical Sciences, University of Padova (Supervisor: Prof. Adriano Guiotto)


Employment

1984 - Research Fellow at R&D ChemLab - GLAXO - Verona

1985 - 1988 PhD fellow at Dept of Pharmaceutical Sciences, University of Padova

1989 - Research Fellow at Dept of Pharmaceutical Sciences - University of Padova

1989 - 2000 Assistant Professor of Medicinal Chemistry, Dept of Pharmaceutical Sciences, University of Padova

From 2000 Associate Professor of Medicinal Chemistry, Dept of Pharmaceutical Sciences, University of Padova

 

Positions

2004-2011 Director of PhD course in Pharmaceutical Sciences – Univ. of Padova

2006-2014 Member of students’ guidance and tutorship committee of Univ.of Padova 

2008-2010 President of Veneto Section of SCI 

2015-2019 Member of Dept Board (DSF UniPD)

2013-2022 Member of the Teaching Commission - School of Medicine – Univ. of Padova

From 2004 Member of the Teachers' Council of PhD course in Molecular Sciences (UniPD)

From 2012 Member of the Teaching Commission - Dept. Pharmaceutical Sciences - Univ. of Padova 

From 2015 Chair of the Degree Course Teachers' Council in Pharmacy (UniPD)

From 2015 Member of Dept Board (DSF UniPD)

From 2014 Member of Teachers' Council in "Scuola di Specializzazione in Farmacia Ospedaliera" (UniPD)

Teaching

  Courses

Adriana Chilin in Syllabus

Medicinal and Toxicological Chemistry 1 for the degree in Pharmacy, 10 CFU

Principles of Medicinal Chemistry for the Degree in Biotechnology, 6 CFU

  Office hours

Monday to Friday by appointment

  Availability for Thesis Projects

Topics for experimental thesis

  • Design, synthesis and studies on new agents to treat cystic fibrosis
  • Design, synthesis and studies of tyrosine kynase inhibitors

Available positions: every year starting from february/march or april/may or november

Topics for non-experimental thesis

  • Trend topics in Medicinal Chemistry, expecially anticancer, antimicrobial, antiviral drugs and cardiovascular drugs

Research 

  Scientific Activities

Furocoumarin derivatives and pyrazolopyrimidinone derivatives as modulator of CFTR function for the treatment of cystic fibrosis. Design and preparation by conventional synthetic methodologies and/or microwave assisted synthesis (MAOS). Biological evaluation.

Tyrosine kinase inhibitors. Synthesis by conventional and MAOS techniques. Evaluation of the biological activity profile of the compounds. Refinement of QSAR models for rational design of new inhibitors.

Identification of organic compounds through 1H-NMR and 13C-NMR spectroscopy and Mass spectrometry.

Coordinator of research projects funded by MIUR, Università di Padova and FFC (Fondazione Fibrosi Cistica)

Member of scientific societies (ACS American Chemical Society; SCI Societa Chimica Italiana)

Peer reviewer of many international journals on Organic Synthesis and Medicinal Chemistry

  Technical expertise

Organic synthesis and Microwave Assisted Organic Synthesis (expecially in the field of furocoumarins, quinazoline and pyrimidine derivatives), purification techniques, Flash Chromatography, HPLC, IR Spectroscopy, 1D and 2D NMR Spectroscopy, Mass Spectrometry

  Positions available

  Publications

  1. Milani, R; Brognara, E; Fabbri, E; Finotti, A; Borgatti, M; Lampronti, I; Marzaro, G; Chilin, A; Lee, Kk; Kok, Sh; Chui, Ch; Gambari, R. Corilagin Induces High Levels of Apoptosis in the Temozolomide-Resistant T98G Glioma Cell Line. Oncology research, Epub 04 may 2017 DOI: 10.3727/096504017X14928634401187 
  2. Mologni L, Dalla Via M, Chilin A, Palumbo M, Marzaro G. Discovery of novel wtRET and V804MRET inhibitors: from hit to lead. ChemMedChem. Epub 2017 Jun 22. doi: 10.1002/cmdc.201700243.
  3. I. Lampronti, MG. Manzione, G. Sacchetti, D. Ferrari, S. Spisani, V. Bezzerri, A. Finotti, M. Borgatti, MC. Dechecchi, G. Miolo,  G. Marzaro, G. Cabrini, R. Gambari, A. Chilin. Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells, Mediators of Inflammation, 2017, article ID 2389487. DOI:10.1155/2017/238948.
  4. G. Marzaro, I. Lampronti, E. D’Aversa, G. Sacchetti, G. Miolo, C. Vaccarin, G. Cabrini, MC. Dechecchi, R. Gambari, A. Chilin. Design, Synthesis and Biological Evaluation of Novel Trimethylangelicin Analogues Targeting Nuclear Factor κB (NF-κB). Eur. J. Med. Chem., 151, 285-293 (2018), DOI: 10.1016/j.ejmech.2018.03.080
  5. O. Laselva, G. Marzaro, C. Vaccarin, I. Lampronti, A. Tamanini, G. Lippi, R. Gambari, G. Cabrini, CE. Bear, A. Chilin, MC. Dechecchi. Molecular mechanism of action of Trimethylangelicin derivatives as CFTR modulators. Frontiers in Pharmacology, 2018 DOI:10.3389/fphar.2018.00719
  6.  Milani R, Brognara E, Fabbri E, Finotti A, Borgatti M, Lampronti I, Marzaro G, Chilin A, Lee KK, Kok SH, Chui CH, Gambari R. Corilagin Induces High Levels of Apoptosis in the Temozolomide-Resistant T98G Glioma Cell Line. Oncol Res. 2018 Oct 17;26(9):1307-1315. doi: 10.3727/096504017X14928634401187.
  7. Chung PY, Lam PL, Zhou YY, Gasparello J, Finotti A, Chilin A, Marzaro G, Gambari R, Bian ZX, Kwok WM, Wong WY, Wang X, Lam AK, Chan AS, Li X, Ma JY, Chui CH, Lam KH, Tang JC. Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma. Cells. 2018 Oct 22;7(10):177. doi: 10.3390/cells7100177.
  8.  Gemmo C, Breveglieri G, Marzaro G, Lampronti I, Cosenza LC, Gasparello J, Zuccato C, Fabbri E, Borgatti M, Chilin A, Finotti A, Gambari R. Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia. Anal Bioanal Chem. 2019 Nov;411(29):7699-7707. doi: 10.1007/s00216-019-01987-9.
  9.  Salmaso S, Mastrotto F, Roverso M, Gandin V, De Martin S, Gabbia D, De Franco M, Vaccarin C, Verona M, Chilin A, Caliceti P, Bogialli S, Marzaro G. Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment. J Control Release. 2021 Dec 10;340:318-330. doi: 10.1016/j.jconrel.2021.11.006.
  10. 10.  Di Liddo R, Verona M, Vaccarin C, Acquasaliente L, Schrenk S, Piccione M, Cenzi C, De Franco M, Dal Prà M, Ribaudo G, Ferlin MG, Conconi MT, Chilin A, Gandin V, Marzaro G. Preliminary Discovery of Small Molecule Inhibitors of Epidermal Growth Factor Receptor (EGFR) That Bind to the Extracellular Domain. Cancers (Basel). 2022 Jul 27;14(15):3647. doi: 10.3390/cancers14153647.
  11. Franceschinis, E.; Roverso, M.; Gabbia, D.; De Martin, S.; Brusegan, M.; Vaccarin, C.; Bogialli, S.; Chilin, A. Self-Emulsifying Formulations to Increase the Oral Bioavailability of 4,6,4’-Trimethylangelicin as a Possible Treatment for Cystic Fibrosis. Pharmaceutics 2022, 14, 1806. https://doi.org/10.3390/pharmaceutics14091806
  12. Costa E, Domenica Cappellini M, Rivella S, Chilin A, Alessi E, Riccaboni M, Leufkens HGM, Luzzatto L. Emergent treatments for β-thalassemia and orphan drug legislations. Drug Discov Today. 2022 Sep 1:103342. doi: 10.1016/j.drudis.2022.103342

  Complete list of publications

Adriana Chilin in Padua Research Archive IRIS (Institutional Research Information System)

  Patents

F. Baccichetti, F.Bordin, S. Caffieri, F. Carlassare, F. Dall'Acqua, A. Guiotto, P. Rodighiero, D. Vedaldi, A. Chilin, M. Cristofolini, G. Recchia. Isostero angelicinico con duplice attività antiproliferativa, metodo per la sua preparazione e suoi impieghi in terapia. - Brevetto nazionale n° VE94A000037 depositato il 09.08.94.

A. Guiotto, M. Dalle Carbonare, A. Chilin, G. Pastorini. Uso di nuovi composti endocannabinoido simili, nonché metodo di preparazione e composizioni farmaceutiche ottenibili con gli stessi. Brevetto nazionale n° PD2005A346 depositato il 29.11.2005.

A. Chilin, G. Marzaro, A. Guiotto, M.T. Conconi, I. Castagliuolo. Inibitori multitirosinchinasi utili per le patologie correlate: modelli farmacoforici, composti identificati tramite questi modelli, metodi per la loro preparazione, la loro formulazione e il loro impiego terapeutico. Brevetto nazionale n° PD2011A000091 depositato il 24.03.2011.

A. Chilin, G. Marzaro, A. Guiotto, M.T. Conconi, I. Castagliuolo. Biphenyl tricyclic quinazoline compounds. Brevetto Internazionale Application No. PCT/EP2012/055145 (22.03.2012), Pubblication No. WO2012127012 (27.09.2012).

  Research projects and Funds

2022-2024 - Towards the development of GY-971a as anti-inflammatory drug in Cystic Fibrosis, Fondazione Fibrosi Cistica, Progetto FFC #10/2022 Collaborator

2021-2022 - Toward the development of tailored therapies for insensitive CF gating mutations, Fondazione Fibrosi Cistica, Progetto FFC #3/2021 Principal Investigator

2018-2020 - Preclinical characterization of new TMA analogues as CFTR modulators, Progetto di Ateneo 2018, Università di Padova, PRID2018, Principal Investigator

2016-2018 - New generation trimethylangelicin (TMA) analogues for selective modulation of defective CFTR or inflammation, Fondazione Fibrosi Cistica, Progetto FFC #1/2016, Principal Investigator

2014-2015 - Design and synthesis of improved analogs of trimethylangelicin (TMA) for personalized treatment of cystic fibrosis, Fondazione Fibrosi Cistica, Progetto FFC #8/2014, RUC 

2011-2013 Progettazione ligand-based e sintesi di nuove molecole per la scoperta di agenti antitumorali attivi come modulatori del ciclo cellulare, PRIN-2009, MIUR - Italian Ministry of Scientific Research, Protocollo 2009PX2T2E_001, P 

2010-2011 - Molecular characterization of trimethylangelicin (TMA) and structurally-related compounds in CF lung disease: anti-inflammatory effects and potentiation of the CFTR biological activity, Fondazione Fibrosi Cistica, Progetto FFC #17/2010, P 

2009-2010 Sintesi di nuovi derivati chinazolinici antagonisti dell’ATP per la terapia antitumorale combinata anti-EGFR e anti-VEGFR, Assegno di Ricerca 2008, Università di Padova, CPDR089577/08  

2009-2010 Progettazione razionale, sintesi e valutazione biologica di nuovi inibitori delle tirosin-chinasi: uno studio ad "equilibrio circolare", Progetto di Ateneo 2008, Università di Padova, CPDA084954/08, PI 

2007-2008 - Sintesi e studio di inibitori duali di topo I/II e inibitori di protein chinasi CK2, PRIN-2006, MIUR - Italian Ministry of Scientific Research, Protocollo 2006038137_002, PI 

2005-2006 - Inibitori e/o veleni della topoisomerasi I e II ed inibitori della protein chinasi CK2, PRIN-2002, MIUR - Italian Ministry of Scientific Research, Protocollo 2004030405_010, P

2003-2004 Determinanti molecolari nell'inibizione e/o avvelenamento delle topoisomerasi I e II, PRIN-2002, MIUR - Italian Ministry of Scientific Research, Protocollo 2002033121_006, P 

1998-1999 - Progettazione, sintesi e studio di agenti chemio e fotochemioterapici, PRIN-1997, MIUR - Italian Ministry of Scientific Research, Protocollo 9703028183_032, P