Adriana Chilin

Adriana Chilin

Department of Pharmaceutical and Pharmacological Sciences, University of Padova
via F. Marzolo 5, 35131 Padova - Italy

Position: Associate Professor of Medicinal Chemistry (SSD CHIM/08)

Contacts
Phone: +39-049-827-5349
Fax:  +39-049-827-5366
e-mail: adriana.chilin@unipd.it

  Short CV

Born in Padova on 02/08/1959


Education and Training

1983 - Degree summa cum laude in Pharmaceutical Chemistry and Technology, University of Padova

1985-1988 - PhD in Pharmaceutical Sciences, Dept of Pharmaceutical Sciences, University of Padova (Supervisor: Prof. Adriano Guiotto)


Employment

1984 - Research Fellow at R&D ChemLab - GLAXO - Verona

1985 - 1988 PhD fellow at Dept of Pharmaceutical Sciences, University of Padova

1989 - Research Fellow at Dept of Pharmaceutical Sciences - University of Padova

1989 - 2000 Assistant Professor of Medicinal Chemistry, Dept of Pharmaceutical Sciences, University of Padova

From 2000 Associate Professor of Medicinal Chemistry, Dept of Pharmaceutical Sciences, University of Padova

 

Positions

2004-2011 Director of PhD course in Pharmaceutical Sciences – Univ. of Padova

From 2004 Member of the Teachers' Council of PhD course in Molecular Sciences (UniPD)

2006-2014 Member of students’ guidance and tutorship committee of Univ.of Padova 

2008-2010 President of Veneto Section of SCI 

From 2012 Coordinator of the Teaching Commission - Dept. Pharmaceutical Sciences - Univ. of Padova 

From 2013 Member of the Teaching Commission - School of Medicine – Univ. of Padova

From 2015 Chair of the Degree Course Teachers' Council in Pharmacy (UniPD)

From 2015 Member of Dept Board (DSF UniPD)

From 2014 Member of Teachers' Council in "Scuola di Specializzazione in Farmacia Ospedaliera" (UniPD)

Teaching

  Courses

Adriana Chilin in Syllabus

Medicinal and Toxicological Chemistry 1 for the degree in Pharmacy, 10 CFU

Principles of Medicinal Chemistry for the Degree in Biotechnology, 7 CFU

  Office hours

Monday to Friday by appointment

  Availability for Thesis Projects

Topics for experimental thesis

  • Design, synthesis and studies on new agents to treat cystic fibrosis
  • Design, synthesis and studies of furocoumarines as NF-kB inhibitors
  • Design, synthesis and studies on quinazoline-based tubulin inhibitors

Available positions: every year starting from february/march or april/may or november

Topics for non-experimental thesis

  • Trend topics in Medicinal Chemistry, expecially anticancer, antimicrobial, antiviral drugs and cardiovascular drugs

Research 

  Scientific Activities

Furocoumarin derivatives as modulator of CFTR function for the treatment of cystic fibrosis. Design and preparation by conventional synthetic methodologies and/or microwave assisted synthesis (MAOS). Biological evaluation.

Coumarin and quinolinone derivatives. Synthesis by MAOS. Evaluation as kinase inhibitors.

New potential topoisomerase I and II inhibitors with heterocyclic structures. Rational design and synthesis. Evaluation of the antiproliferative and antitopoisomerase activity.

Quinazoline-based compounds as ATP-mimetic tyrosine kinase inhibitors. Setting up of new strategies for the synthesis of quinazoline nucleus and of 4-anilinoquinazoline derivatives by conventional and MAOS techniques. Evaluation of the biological activity profile of the compounds. Refinement of QSAR models for rational design of new inhibitors.

Non-peptidomimetic proteasome inhibitors with psoralenquinone structure. Synthesis and evaluation of the inhibitory potency on the catalytic activity. Study of the selectivity profile of the compounds. Rationalization of the activity and selectivity profiles through molecular docking studies.

NF-kB inhibitors with furocoumarin structure. Refinement and setting up of novel synthetic strategies by MAOS. Biological evaluation.

Identification of organic compounds through 1H-NMR and 13C-NMR spectroscopy and Mass spectrometry.

Coordinator of research projects funded by MIUR, Università di Padova and FFC (Fondazione Fibrosi Cistica)

Member of scientific societies (ACS American Chemical Society; SCI Societa Chimica Italiana)

Peer reviewer of many international journals on Organic Synthesis and Medicinal Chemistry

  Technical expertise

Organic synthesis and Microwave Assisted Organic Synthesis (expecially in the field of furocoumarins, quinazoline and pyrimidine derivatives), purification techniques, Flash Chromatography, HPLC, IR Spectroscopy, 1D and 2D NMR Spectroscopy, Mass Spectrometry

  Positions available

  Publications

  1. G. Marzaro, I. Lampronti, E. D’Aversa, G. Sacchetti, G. Miolo, C. Vaccarin, G. Cabrini, MC. Dechecchi, R. Gambari, A. Chilin. Design, Synthesis and Biological Evaluation of Novel Trimethylangelicin Analogues Targeting Nuclear Factor κB (NF-κB). Eur. J. Med. Chem., 151, 285-293 (2018),  DOI:10.1016/j.ejmech.2018.03.080
  2. I. Lampronti, MG. Manzione, G. Sacchetti, D. Ferrari, S. Spisani, V. Bezzerri, A. Finotti, M. Borgatti, MC. Dechecchi, G. Miolo,  G. Marzaro, G. Cabrini, R. Gambari, A. Chilin. Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells, Mediators of Inflammation, DOI:10.1155/2017/238948.
  3. Mologni L, Dalla Via M, Chilin A, Palumbo M, Marzaro G. Discovery of novel wtRET and V804MRET inhibitors: from hit to lead. ChemMedChem. 2017 doi:10.1002/cmdc.201700243.
  4. Milani, R; Brognara, E; Fabbri, E; Finotti, A; Borgatti, M; Lampronti, I; Marzaro, G; Chilin, A; Lee, Kk; Kok, Sh; Chui, Ch; Gambari, R. Corilagin Induces High Levels of Apoptosis in the Temozolomide-Resistant T98G Glioma Cell Line. Oncology research, 2017 DOI:10.3727/096504017X14928634401187
  5. Di Giovanni, C; Novellino, E; Chilin, A; Lavecchia, A; Marzaro, G. Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016). Expert Opinion On Investigational Drugs 25, 1215-1230 (2016). doi:10.1080/13543784.2016.1234603.
  6. G. Marzaro, L. Dalla Via, A.N. García-Argáez, M. Dalla Via, A. Chilin. Novel benzoquinoline derivatives via unpredicted condensation of ethyl propiolate and naphthylamines: Synthesis and topoisomerase inhibition activity. Bioorganic & Medicinal Chemistry Letters - 26, 4875-4878 (2016). DOI:10.1016/j.bmcl.2016.09.031
  7. G. Marzaro, I. Castagliuolo, G. Schirato, G. Palu', M. Dalla Via, A. Chilin, P. Brun*. Substituted quinazolinones as kinase inhibitors endowed with anti-fibrotic properties, Eur. J. Med. Chem., 115, 416-425 (2016), DOI:10.1016/j.ejmech.2016.03.053
  8. Bianchi, Nicoletta; Cosenza, Lucia Carmela; Lampronti, Ilaria; Finotti, Alessia; Breveglieri, Giulia; Zuccato, Cristina; Fabbri, Enrica; Marzaro, Giovanni; Chilin, Adriana; De Angelis, Gioia; Borgatti, Monica; Gallucci, Cristiano; Alfieri, Cecilia; Ribersani, Michela; Isgrò, Antonella; Marziali, Marco; Gaziev, Javid; Morrone, Aldo; Sodani, Pietro; Lucarelli, Guido; Gambari, Roberto; Paciaroni, Katia. Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β(0)-Thalassemia Families with High Fetal Hemoglobin Levels, Mol. Diagn. Ther., 20, 161-173 (2016). DOI:10.1007/s40291-016-0187-2
  9. V. Gandin, A. Ferrarese, M. Dalla Via, C. Marzano, A. Chilin, G. Marzaro. Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily. Sci. Rep. 5, 16750 (2015). DOI:10.1038/srep16750
  10. L. Dalla Via, G. Marzaro, A. Mazzoli, A. Chilin, G. Miolo. Photobiological properties of 3-psoralenacetic acids. Photochem. Photobiol. Sci., 14, 2074-86 (2015). DOI:10.1039/c5pp00210a

  Complete list of publications

Adriana Chilin in Padua Research Archive IRIS (Institutional Research Information System)

  Patents

F. Baccichetti, F.Bordin, S. Caffieri, F. Carlassare, F. Dall'Acqua, A. Guiotto, P. Rodighiero, D. Vedaldi, A. Chilin, M. Cristofolini, G. Recchia. Isostero angelicinico con duplice attività antiproliferativa, metodo per la sua preparazione e suoi impieghi in terapia. - Brevetto nazionale n° VE94A000037 depositato il 09.08.94.

A. Guiotto, M. Dalle Carbonare, A. Chilin, G. Pastorini. Uso di nuovi composti endocannabinoido simili, nonché metodo di preparazione e composizioni farmaceutiche ottenibili con gli stessi. Brevetto nazionale n° PD2005A346 depositato il 29.11.2005.

A. Chilin, G. Marzaro, A. Guiotto, M.T. Conconi, I. Castagliuolo. Inibitori multitirosinchinasi utili per le patologie correlate: modelli farmacoforici, composti identificati tramite questi modelli, metodi per la loro preparazione, la loro formulazione e il loro impiego terapeutico. Brevetto nazionale n° PD2011A000091 depositato il 24.03.2011.

A. Chilin, G. Marzaro, A. Guiotto, M.T. Conconi, I. Castagliuolo. Biphenyl tricyclic quinazoline compounds. Brevetto Internazionale Application No. PCT/EP2012/055145 (22.03.2012), Pubblication No. WO2012127012 (27.09.2012).

  Research projects and Funds

2016-2018 - New generation trimethylangelicin (TMA) analogues for selective modulation of defective CFTR or inflammation, Fondazione Fibrosi Cistica, Progetto FFC #1/2016, Principal Investigator

2014-2015 - Design and synthesis of improved analogs of trimethylangelicin (TMA) for personalized treatment of cystic fibrosis, Fondazione Fibrosi Cistica, Progetto FFC #8/2014, RUC 

2011-2013 Progettazione ligand-based e sintesi di nuove molecole per la scoperta di agenti antitumorali attivi come modulatori del ciclo cellulare, PRIN-2009, MIUR - Italian Ministry of Scientific Research, Protocollo 2009PX2T2E_001, P 

2010-2011 - Molecular characterization of trimethylangelicin (TMA) and structurally-related compounds in CF lung disease: anti-inflammatory effects and potentiation of the CFTR biological activity, Fondazione Fibrosi Cistica, Progetto FFC #17/2010, P 

2009-2010 Sintesi di nuovi derivati chinazolinici antagonisti dell’ATP per la terapia antitumorale combinata anti-EGFR e anti-VEGFR, Assegno di Ricerca 2008, Università di Padova, CPDR089577/08  

2009-2010 Progettazione razionale, sintesi e valutazione biologica di nuovi inibitori delle tirosin-chinasi: uno studio ad "equilibrio circolare", Progetto di Ateneo 2008, Università di Padova, CPDA084954/08, PI 

2007-2008 - Sintesi e studio di inibitori duali di topo I/II e inibitori di protein chinasi CK2, PRIN-2006, MIUR - Italian Ministry of Scientific Research, Protocollo 2006038137_002, PI 

2005-2006 - Inibitori e/o veleni della topoisomerasi I e II ed inibitori della protein chinasi CK2, PRIN-2002, MIUR - Italian Ministry of Scientific Research, Protocollo 2004030405_010, P

2003-2004 Determinanti molecolari nell'inibizione e/o avvelenamento delle topoisomerasi I e II, PRIN-2002, MIUR - Italian Ministry of Scientific Research, Protocollo 2002033121_006, P 

1998-1999 - Progettazione, sintesi e studio di agenti chemio e fotochemioterapici, PRIN-1997, MIUR - Italian Ministry of Scientific Research, Protocollo 9703028183_032, P